Discovery of Highly Potent Liver X Receptor β Agonists

[Image: see text] Introducing a uniquely substituted phenyl sulfone into a series of biphenyl imidazole liver X receptor (LXR) agonists afforded a dramatic potency improvement for induction of ATP binding cassette transporters, ABCA1 and ABCG1, in human whole blood. The agonist series demonstrated r...

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Autores principales: Kick, Ellen K., Busch, Brett B., Martin, Richard, Stevens, William C., Bollu, Venkataiah, Xie, Yinong, Boren, Brant C., Nyman, Michael C., Nanao, Max H., Nguyen, Lam, Plonowski, Artur, Schulman, Ira G., Yan, Grace, Zhang, Huiping, Hou, Xiaoping, Valente, Meriah N., Narayanan, Rangaraj, Behnia, Kamelia, Rodrigues, A. David, Brock, Barry, Smalley, James, Cantor, Glenn H., Lupisella, John, Sleph, Paul, Grimm, Denise, Ostrowski, Jacek, Wexler, Ruth R., Kirchgessner, Todd, Mohan, Raju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150697/
https://www.ncbi.nlm.nih.gov/pubmed/27994765
http://dx.doi.org/10.1021/acsmedchemlett.6b00234

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