p53 activates miR-192-5p to mediate vancomycin induced AKI

Pathogenic role of p53 in AKI remains controversial and the underlying mechanism is unclear. Here, we tested whether the inhibition of p53 may ameliorate vancomycin (VAN) induced acute kidney injury (AKI). Mice with p53 knock out (p53-KO) were resistant to VAN induced AKI, indicated by the analysis...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Jinwen, Wang, Juan, Li, Huiling, Wang, Shixuan, Xiang, Xudong, Zhang, Dongshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150818/
https://www.ncbi.nlm.nih.gov/pubmed/27941921
http://dx.doi.org/10.1038/srep38868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150818/
https://www.ncbi.nlm.nih.gov/pubmed/27941921
http://dx.doi.org/10.1038/srep38868

Ejemplares similares