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p53 activates miR-192-5p to mediate vancomycin induced AKI
Pathogenic role of p53 in AKI remains controversial and the underlying mechanism is unclear. Here, we tested whether the inhibition of p53 may ameliorate vancomycin (VAN) induced acute kidney injury (AKI). Mice with p53 knock out (p53-KO) were resistant to VAN induced AKI, indicated by the analysis...
Autores principales: | Chen, Jinwen, Wang, Juan, Li, Huiling, Wang, Shixuan, Xiang, Xudong, Zhang, Dongshan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150818/ https://www.ncbi.nlm.nih.gov/pubmed/27941921 http://dx.doi.org/10.1038/srep38868 |
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