Roles of interleukin-17 in uveitis

Th17 cells, a CD4(+) T-cell subset, produce interleukin (IL)-17, a pro-inflammatory cytokine that has been shown to be involved in several forms of infectious and noninfectious uveitis. Here, we explore the roles of this IL in uveitic disorders as well as in experimental autoimmune uveitis, the poss...

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Detalles Bibliográficos
Autores principales: Guedes, Marta Catarina Esteves, Borrego, Luis Miguel, Proença, Rui Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151150/
https://www.ncbi.nlm.nih.gov/pubmed/27853008
http://dx.doi.org/10.4103/0301-4738.194339
Descripción
Sumario:Th17 cells, a CD4(+) T-cell subset, produce interleukin (IL)-17, a pro-inflammatory cytokine that has been shown to be involved in several forms of infectious and noninfectious uveitis. Here, we explore the roles of this IL in uveitic disorders as well as in experimental autoimmune uveitis, the possible pathogenic implications of several cytokines associated with IL-17 and analyze the current outcomes and goals for drugs aiming for the IL-17 pathway.

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