Roles of interleukin-17 in uveitis

Th17 cells, a CD4(+) T-cell subset, produce interleukin (IL)-17, a pro-inflammatory cytokine that has been shown to be involved in several forms of infectious and noninfectious uveitis. Here, we explore the roles of this IL in uveitic disorders as well as in experimental autoimmune uveitis, the poss...

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Autores principales: Guedes, Marta Catarina Esteves, Borrego, Luis Miguel, Proença, Rui Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151150/
https://www.ncbi.nlm.nih.gov/pubmed/27853008
http://dx.doi.org/10.4103/0301-4738.194339
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author Guedes, Marta Catarina Esteves
Borrego, Luis Miguel
Proença, Rui Daniel
author_facet Guedes, Marta Catarina Esteves
Borrego, Luis Miguel
Proença, Rui Daniel
author_sort Guedes, Marta Catarina Esteves
collection PubMed
description Th17 cells, a CD4(+) T-cell subset, produce interleukin (IL)-17, a pro-inflammatory cytokine that has been shown to be involved in several forms of infectious and noninfectious uveitis. Here, we explore the roles of this IL in uveitic disorders as well as in experimental autoimmune uveitis, the possible pathogenic implications of several cytokines associated with IL-17 and analyze the current outcomes and goals for drugs aiming for the IL-17 pathway.
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spelling pubmed-51511502016-12-20 Roles of interleukin-17 in uveitis Guedes, Marta Catarina Esteves Borrego, Luis Miguel Proença, Rui Daniel Indian J Ophthalmol Review Article Th17 cells, a CD4(+) T-cell subset, produce interleukin (IL)-17, a pro-inflammatory cytokine that has been shown to be involved in several forms of infectious and noninfectious uveitis. Here, we explore the roles of this IL in uveitic disorders as well as in experimental autoimmune uveitis, the possible pathogenic implications of several cytokines associated with IL-17 and analyze the current outcomes and goals for drugs aiming for the IL-17 pathway. Medknow Publications & Media Pvt Ltd 2016-09 /pmc/articles/PMC5151150/ /pubmed/27853008 http://dx.doi.org/10.4103/0301-4738.194339 Text en Copyright: © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Guedes, Marta Catarina Esteves
Borrego, Luis Miguel
Proença, Rui Daniel
Roles of interleukin-17 in uveitis
title Roles of interleukin-17 in uveitis
title_full Roles of interleukin-17 in uveitis
title_fullStr Roles of interleukin-17 in uveitis
title_full_unstemmed Roles of interleukin-17 in uveitis
title_short Roles of interleukin-17 in uveitis
title_sort roles of interleukin-17 in uveitis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151150/
https://www.ncbi.nlm.nih.gov/pubmed/27853008
http://dx.doi.org/10.4103/0301-4738.194339
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