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Outcome of transplanted donor corneas with more than 6 h of death-to-preservation time

PURPOSE: In tropical countries, physicians are skeptic in using corneas with death-to-preservation time (DTPT) >6 h, concerns being endothelial cell viability and microbial contamination on prolonged DTPT. The objective of the study was to investigate these concerns by analyzing the outcomes of c...

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Autores principales: Mohamed, Ashik, Chaurasia, Sunita, Garg, Prashant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151151/
https://www.ncbi.nlm.nih.gov/pubmed/27853009
http://dx.doi.org/10.4103/0301-4738.194338
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author Mohamed, Ashik
Chaurasia, Sunita
Garg, Prashant
author_facet Mohamed, Ashik
Chaurasia, Sunita
Garg, Prashant
author_sort Mohamed, Ashik
collection PubMed
description PURPOSE: In tropical countries, physicians are skeptic in using corneas with death-to-preservation time (DTPT) >6 h, concerns being endothelial cell viability and microbial contamination on prolonged DTPT. The objective of the study was to investigate these concerns by analyzing the outcomes of corneal transplants performed using donor corneas with DTPT >6 h. MATERIALS AND METHODS: The study was a retrospective case series of 65 transplants performed in 2013 with donor corneas that had DTPT >6 h (range, 6.1–9.8 h). The information on donor cornea tissues and the recipient details were collected from the eye bank and the medical records department of our tertiary eye care center. The main outcome measures were slit lamp assessment of the donor corneas, primary graft failure, graft survival, and postoperative adverse reactions, especially infections, if any. RESULTS: Median DTPT was 7 h. Forty-four (67.7%) corneas were evaluated as optical grade and 21 (32.3%) were deemed as therapeutic grade; 36 (55.4%) were used for optical indications. There was no relationship between DTPT and the tissue grading of corneas or endothelial cell density. Of the 23 keratoplasties for purely optical indications with a minimum follow-up of 3 months, 15 (65.2%) remained clear whereas 7 (30.4%) failed (mean follow-up 15.1 ± 6.7 months). The causes of failure were primary graft failure (n = 1) and secondary graft failure (n = 6). CONCLUSION: : The donor corneas with DTPT 6 h to 10 h can be utilized for optical indications provided that they meet the criteria of tissue acceptance for optical use.
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spelling pubmed-51511512016-12-20 Outcome of transplanted donor corneas with more than 6 h of death-to-preservation time Mohamed, Ashik Chaurasia, Sunita Garg, Prashant Indian J Ophthalmol Original Article PURPOSE: In tropical countries, physicians are skeptic in using corneas with death-to-preservation time (DTPT) >6 h, concerns being endothelial cell viability and microbial contamination on prolonged DTPT. The objective of the study was to investigate these concerns by analyzing the outcomes of corneal transplants performed using donor corneas with DTPT >6 h. MATERIALS AND METHODS: The study was a retrospective case series of 65 transplants performed in 2013 with donor corneas that had DTPT >6 h (range, 6.1–9.8 h). The information on donor cornea tissues and the recipient details were collected from the eye bank and the medical records department of our tertiary eye care center. The main outcome measures were slit lamp assessment of the donor corneas, primary graft failure, graft survival, and postoperative adverse reactions, especially infections, if any. RESULTS: Median DTPT was 7 h. Forty-four (67.7%) corneas were evaluated as optical grade and 21 (32.3%) were deemed as therapeutic grade; 36 (55.4%) were used for optical indications. There was no relationship between DTPT and the tissue grading of corneas or endothelial cell density. Of the 23 keratoplasties for purely optical indications with a minimum follow-up of 3 months, 15 (65.2%) remained clear whereas 7 (30.4%) failed (mean follow-up 15.1 ± 6.7 months). The causes of failure were primary graft failure (n = 1) and secondary graft failure (n = 6). CONCLUSION: : The donor corneas with DTPT 6 h to 10 h can be utilized for optical indications provided that they meet the criteria of tissue acceptance for optical use. Medknow Publications & Media Pvt Ltd 2016-09 /pmc/articles/PMC5151151/ /pubmed/27853009 http://dx.doi.org/10.4103/0301-4738.194338 Text en Copyright: © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Mohamed, Ashik
Chaurasia, Sunita
Garg, Prashant
Outcome of transplanted donor corneas with more than 6 h of death-to-preservation time
title Outcome of transplanted donor corneas with more than 6 h of death-to-preservation time
title_full Outcome of transplanted donor corneas with more than 6 h of death-to-preservation time
title_fullStr Outcome of transplanted donor corneas with more than 6 h of death-to-preservation time
title_full_unstemmed Outcome of transplanted donor corneas with more than 6 h of death-to-preservation time
title_short Outcome of transplanted donor corneas with more than 6 h of death-to-preservation time
title_sort outcome of transplanted donor corneas with more than 6 h of death-to-preservation time
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151151/
https://www.ncbi.nlm.nih.gov/pubmed/27853009
http://dx.doi.org/10.4103/0301-4738.194338
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