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Cluster endophthalmitis following multiple intravitreal bevacizumab injections from a single use vial
The risk of endophthalmitis is always a concern when an intraocular procedure is performed. Intravitreal injection is a frequently used method for therapeutic management of many diseases, affecting the posterior segment of the eye. Hence, it is important to assess the risk of complications, especial...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151169/ https://www.ncbi.nlm.nih.gov/pubmed/27853027 http://dx.doi.org/10.4103/0301-4738.99855 |
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author | Khan, Perwez Khan, Lubna Mondal, Prosenjit |
author_facet | Khan, Perwez Khan, Lubna Mondal, Prosenjit |
author_sort | Khan, Perwez |
collection | PubMed |
description | The risk of endophthalmitis is always a concern when an intraocular procedure is performed. Intravitreal injection is a frequently used method for therapeutic management of many diseases, affecting the posterior segment of the eye. Hence, it is important to assess the risk of complications, especially endophthalmitis. Most studies conducted concentrate on risk assessment from single use from single drug vial. The present article reports the occurrence of cluster endophthalmitis following multiple intravitreal bevacizumab injections from a single vial. Intravitreal injection of bevacizumab was administered to eight eyes of eight patients. Administered dose was prepared from single 4-ml vial of bevacizumab and was injected in the eye, after patient preparation and under aseptic conditions. The procedure was repeated for the remaining patients, thereby imparting multiple pricks in the same vial. Four of the eight patients reported to the hospital on the 3rd day after injection with complaints of pain, watering, and diminution of vision. Two patients reported the following day with similar complaints. Two patients who did not report by the 4th day were contacted and recalled for an examination. All the patients were thoroughly examined using slit lamp biomicroscopy and indirect ophthalmoscopy. Six out of eight were clinically diagnosed to have endophthalmitis and were administered intravitreal antibiotics. The present report highlights possibility of microbial contamination of the drug vial or during compounding process. However, from the present incident, we are encouraged to stay vigilant and wary of contamination |
format | Online Article Text |
id | pubmed-5151169 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-51511692016-12-20 Cluster endophthalmitis following multiple intravitreal bevacizumab injections from a single use vial Khan, Perwez Khan, Lubna Mondal, Prosenjit Indian J Ophthalmol Brief Communication The risk of endophthalmitis is always a concern when an intraocular procedure is performed. Intravitreal injection is a frequently used method for therapeutic management of many diseases, affecting the posterior segment of the eye. Hence, it is important to assess the risk of complications, especially endophthalmitis. Most studies conducted concentrate on risk assessment from single use from single drug vial. The present article reports the occurrence of cluster endophthalmitis following multiple intravitreal bevacizumab injections from a single vial. Intravitreal injection of bevacizumab was administered to eight eyes of eight patients. Administered dose was prepared from single 4-ml vial of bevacizumab and was injected in the eye, after patient preparation and under aseptic conditions. The procedure was repeated for the remaining patients, thereby imparting multiple pricks in the same vial. Four of the eight patients reported to the hospital on the 3rd day after injection with complaints of pain, watering, and diminution of vision. Two patients reported the following day with similar complaints. Two patients who did not report by the 4th day were contacted and recalled for an examination. All the patients were thoroughly examined using slit lamp biomicroscopy and indirect ophthalmoscopy. Six out of eight were clinically diagnosed to have endophthalmitis and were administered intravitreal antibiotics. The present report highlights possibility of microbial contamination of the drug vial or during compounding process. However, from the present incident, we are encouraged to stay vigilant and wary of contamination Medknow Publications & Media Pvt Ltd 2016-09 /pmc/articles/PMC5151169/ /pubmed/27853027 http://dx.doi.org/10.4103/0301-4738.99855 Text en Copyright: © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Brief Communication Khan, Perwez Khan, Lubna Mondal, Prosenjit Cluster endophthalmitis following multiple intravitreal bevacizumab injections from a single use vial |
title | Cluster endophthalmitis following multiple intravitreal bevacizumab injections from a single use vial |
title_full | Cluster endophthalmitis following multiple intravitreal bevacizumab injections from a single use vial |
title_fullStr | Cluster endophthalmitis following multiple intravitreal bevacizumab injections from a single use vial |
title_full_unstemmed | Cluster endophthalmitis following multiple intravitreal bevacizumab injections from a single use vial |
title_short | Cluster endophthalmitis following multiple intravitreal bevacizumab injections from a single use vial |
title_sort | cluster endophthalmitis following multiple intravitreal bevacizumab injections from a single use vial |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151169/ https://www.ncbi.nlm.nih.gov/pubmed/27853027 http://dx.doi.org/10.4103/0301-4738.99855 |
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