1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis

[Image: see text] A Ni/photoredox dual catalytic cross-coupling is disclosed in which a diverse range of (hetero)aryl bromides are used as electrophiles, with 1,4-dihydropyridines serving as precursors to C(sp)(3)-centered alkyl radical coupling partners. The reported method is characterized by its...

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Autores principales: Gutiérrez-Bonet, Álvaro, Tellis, John C., Matsui, Jennifer K., Vara, Brandon A., Molander, Gary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152669/
https://www.ncbi.nlm.nih.gov/pubmed/27990318
http://dx.doi.org/10.1021/acscatal.6b02786
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author Gutiérrez-Bonet, Álvaro
Tellis, John C.
Matsui, Jennifer K.
Vara, Brandon A.
Molander, Gary A.
author_facet Gutiérrez-Bonet, Álvaro
Tellis, John C.
Matsui, Jennifer K.
Vara, Brandon A.
Molander, Gary A.
author_sort Gutiérrez-Bonet, Álvaro
collection PubMed
description [Image: see text] A Ni/photoredox dual catalytic cross-coupling is disclosed in which a diverse range of (hetero)aryl bromides are used as electrophiles, with 1,4-dihydropyridines serving as precursors to C(sp)(3)-centered alkyl radical coupling partners. The reported method is characterized by its extremely mild reaction conditions, enabling access to underexplored cores.
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spelling pubmed-51526692017-10-27 1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis Gutiérrez-Bonet, Álvaro Tellis, John C. Matsui, Jennifer K. Vara, Brandon A. Molander, Gary A. ACS Catal [Image: see text] A Ni/photoredox dual catalytic cross-coupling is disclosed in which a diverse range of (hetero)aryl bromides are used as electrophiles, with 1,4-dihydropyridines serving as precursors to C(sp)(3)-centered alkyl radical coupling partners. The reported method is characterized by its extremely mild reaction conditions, enabling access to underexplored cores. American Chemical Society 2016-10-27 2016-12-02 /pmc/articles/PMC5152669/ /pubmed/27990318 http://dx.doi.org/10.1021/acscatal.6b02786 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Gutiérrez-Bonet, Álvaro
Tellis, John C.
Matsui, Jennifer K.
Vara, Brandon A.
Molander, Gary A.
1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis
title 1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis
title_full 1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis
title_fullStr 1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis
title_full_unstemmed 1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis
title_short 1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis
title_sort 1,4-dihydropyridines as alkyl radical precursors: introducing the aldehyde feedstock to nickel/photoredox dual catalysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152669/
https://www.ncbi.nlm.nih.gov/pubmed/27990318
http://dx.doi.org/10.1021/acscatal.6b02786
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