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Clinical Characteristics and Outcomes of Gastric Cancer Patients Aged over 80 Years: A Retrospective Case-Control Study

BACKGROUND AND AIMS: The average human life expectancy is increasing worldwide, thus the proportion of elderly gastric cancer patients is also increasing. In this case-control study, we investigated the clinical and oncologic outcomes of gastric cancer in patients over 80 years old. METHODS: From Ja...

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Autores principales: Park, Hee Jung, Ahn, Ji Yong, Jung, Hwoon-Yong, Lee, Jeong Hoon, Jung, Kee Wook, Kim, Do Hoon, Choi, Kee Don, Song, Ho June, Lee, Gin Hyug, Kim, Jin-Ho, Han, Seungbong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152853/
https://www.ncbi.nlm.nih.gov/pubmed/27942044
http://dx.doi.org/10.1371/journal.pone.0167615
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author Park, Hee Jung
Ahn, Ji Yong
Jung, Hwoon-Yong
Lee, Jeong Hoon
Jung, Kee Wook
Kim, Do Hoon
Choi, Kee Don
Song, Ho June
Lee, Gin Hyug
Kim, Jin-Ho
Han, Seungbong
author_facet Park, Hee Jung
Ahn, Ji Yong
Jung, Hwoon-Yong
Lee, Jeong Hoon
Jung, Kee Wook
Kim, Do Hoon
Choi, Kee Don
Song, Ho June
Lee, Gin Hyug
Kim, Jin-Ho
Han, Seungbong
author_sort Park, Hee Jung
collection PubMed
description BACKGROUND AND AIMS: The average human life expectancy is increasing worldwide, thus the proportion of elderly gastric cancer patients is also increasing. In this case-control study, we investigated the clinical and oncologic outcomes of gastric cancer in patients over 80 years old. METHODS: From January 2004 to December 2010, 291 patients aged over 80 years old (case group) were diagnosed and treated with gastric cancer at Asan Medical Center, Seoul, Korea. From the same period, 291 patients aged 18 to 80 years old were selected as the control group. The clinical findings and clinical outcomes of gastric cancer were retrospectively reviewed and compared between the two groups. RESULTS: There were significant differences in the overall 5-year survival rate between the case and control groups (30.9% vs. 73.8%, respectively; P<0.001). In patients who received the curative treatment, overall 3- and 5-year survival rates showed 74.3% and 57.9% in case group and 91.6% and 86.5% in the control group. When analysis was confined to resectable elderly patients with a favorable performance, the curative resection group showed significantly better overall 3- and 5-year survival rates than the conservative treatment group (73.7% and 58.8% vs. 29.8% and 0%, respectively). CONCLUSIONS: Although elderly gastric cancer patients show an advanced stage at diagnosis and poor prognosis compared with non-elderly patients, elderly patients with good performance could benefit from curative resection. Thus, the clinical decision whether to undergo curative resection or conservative management should be made on an individualized basis.
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spelling pubmed-51528532016-12-28 Clinical Characteristics and Outcomes of Gastric Cancer Patients Aged over 80 Years: A Retrospective Case-Control Study Park, Hee Jung Ahn, Ji Yong Jung, Hwoon-Yong Lee, Jeong Hoon Jung, Kee Wook Kim, Do Hoon Choi, Kee Don Song, Ho June Lee, Gin Hyug Kim, Jin-Ho Han, Seungbong PLoS One Research Article BACKGROUND AND AIMS: The average human life expectancy is increasing worldwide, thus the proportion of elderly gastric cancer patients is also increasing. In this case-control study, we investigated the clinical and oncologic outcomes of gastric cancer in patients over 80 years old. METHODS: From January 2004 to December 2010, 291 patients aged over 80 years old (case group) were diagnosed and treated with gastric cancer at Asan Medical Center, Seoul, Korea. From the same period, 291 patients aged 18 to 80 years old were selected as the control group. The clinical findings and clinical outcomes of gastric cancer were retrospectively reviewed and compared between the two groups. RESULTS: There were significant differences in the overall 5-year survival rate between the case and control groups (30.9% vs. 73.8%, respectively; P<0.001). In patients who received the curative treatment, overall 3- and 5-year survival rates showed 74.3% and 57.9% in case group and 91.6% and 86.5% in the control group. When analysis was confined to resectable elderly patients with a favorable performance, the curative resection group showed significantly better overall 3- and 5-year survival rates than the conservative treatment group (73.7% and 58.8% vs. 29.8% and 0%, respectively). CONCLUSIONS: Although elderly gastric cancer patients show an advanced stage at diagnosis and poor prognosis compared with non-elderly patients, elderly patients with good performance could benefit from curative resection. Thus, the clinical decision whether to undergo curative resection or conservative management should be made on an individualized basis. Public Library of Science 2016-12-12 /pmc/articles/PMC5152853/ /pubmed/27942044 http://dx.doi.org/10.1371/journal.pone.0167615 Text en © 2016 Park et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Park, Hee Jung
Ahn, Ji Yong
Jung, Hwoon-Yong
Lee, Jeong Hoon
Jung, Kee Wook
Kim, Do Hoon
Choi, Kee Don
Song, Ho June
Lee, Gin Hyug
Kim, Jin-Ho
Han, Seungbong
Clinical Characteristics and Outcomes of Gastric Cancer Patients Aged over 80 Years: A Retrospective Case-Control Study
title Clinical Characteristics and Outcomes of Gastric Cancer Patients Aged over 80 Years: A Retrospective Case-Control Study
title_full Clinical Characteristics and Outcomes of Gastric Cancer Patients Aged over 80 Years: A Retrospective Case-Control Study
title_fullStr Clinical Characteristics and Outcomes of Gastric Cancer Patients Aged over 80 Years: A Retrospective Case-Control Study
title_full_unstemmed Clinical Characteristics and Outcomes of Gastric Cancer Patients Aged over 80 Years: A Retrospective Case-Control Study
title_short Clinical Characteristics and Outcomes of Gastric Cancer Patients Aged over 80 Years: A Retrospective Case-Control Study
title_sort clinical characteristics and outcomes of gastric cancer patients aged over 80 years: a retrospective case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152853/
https://www.ncbi.nlm.nih.gov/pubmed/27942044
http://dx.doi.org/10.1371/journal.pone.0167615
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