Neuroinflammatory and morphological changes in late-life depression: the NIMROD study

We studied neuroinflammation in individuals with late-life depression, as a risk factor for dementia, using [(11)C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood ta...

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Detalles Bibliográficos
Autores principales: Su, L., Faluyi, Y. O., Hong, Y. T., Fryer, T. D., Mak, E., Gabel, S., Hayes, L., Soteriades, S., Williams, G. B., Arnold, R., Passamonti, L., Rodríguez, P. Vázquez, Surendranathan, A., Bevan-Jones, R. W., Coles, J., Aigbirhio, F., Rowe, J. B., O'Brien, J. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal College of Psychiatrists 2016
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152879/
https://www.ncbi.nlm.nih.gov/pubmed/27758838
http://dx.doi.org/10.1192/bjp.bp.116.190165
Descripción
Sumario:We studied neuroinflammation in individuals with late-life depression, as a risk factor for dementia, using [(11)C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood taken to measure C-reactive protein (CRP). We found significantly higher CRP levels in those with late-life depression and raised [(11)C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. Our findings suggest neuroinflammation requires further investigation in late-life depression, both as a possible aetiological factor and a potential therapeutic target.

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