Biophysical Studies of the Induced Dimerization of Human VEGF Receptor 1 Binding Domain by Divalent Metals Competing with VEGF-A

Angiogenesis is tightly regulated through the binding of vascular endothelial growth factors (VEGFs) to their receptors (VEGFRs). In this context, we showed that human VEGFR1 domain 2 crystallizes in the presence of Zn(2+), Co(2+) or Cu(2+) as a dimer that forms via metal-ion interactions and interl...

Descripción completa

Detalles Bibliográficos
Autores principales: Gaucher, Jean-François, Reille-Seroussi, Marie, Gagey-Eilstein, Nathalie, Broussy, Sylvain, Coric, Pascale, Seijo, Bili, Lascombe, Marie-Bernard, Gautier, Benoit, Liu, Wang-Quing, Huguenot, Florent, Inguimbert, Nicolas, Bouaziz, Serge, Vidal, Michel, Broutin, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152890/
https://www.ncbi.nlm.nih.gov/pubmed/27942001
http://dx.doi.org/10.1371/journal.pone.0167755

Ejemplares similares

Ejemplares similares