Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis

Clostridium difficile infection affects a significant number of hospitalized patients in the United States. Two homologous exotoxins, TcdA and TcdB, are the major virulence factors in C. difficile pathogenesis. The toxins are glucosyltransferases that inactivate Rho family-GTPases to disrupt host ce...

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Detalles Bibliográficos
Autores principales: Chandrasekaran, Ramyavardhanee, Kenworthy, Anne K., Lacy, D. Borden
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152916/
https://www.ncbi.nlm.nih.gov/pubmed/27942025
http://dx.doi.org/10.1371/journal.ppat.1006070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152916/
https://www.ncbi.nlm.nih.gov/pubmed/27942025
http://dx.doi.org/10.1371/journal.ppat.1006070

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