Cargando…

The DPP4 Inhibitor Linagliptin Protects from Experimental Diabetic Retinopathy

BACKGROUND/AIMS: Dipeptidyl peptidase 4 (DPP4) inhibitors improve glycemic control in type 2 diabetes, however, their influence on the retinal neurovascular unit remains unclear. METHODS: Vasculo- and neuroprotective effects were assessed in experimental diabetic retinopathy and high glucose-cultiva...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dietrich, Nadine, Kolibabka, Matthias, Busch, Stephanie, Bugert, Petra, Kaiser, Ulrike, Lin, Jihong, Fleming, Thomas, Morcos, Michael, Klein, Thomas, Schlotterer, Andrea, Hammes, Hans-Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152931/ https://www.ncbi.nlm.nih.gov/pubmed/27942008 http://dx.doi.org/10.1371/journal.pone.0167853

Ejemplares similares

The effect of GLP-1 receptor agonist lixisenatide on experimental diabetic retinopathy
por: Oezer, Kuebra, et al.
Publicado: (2023)

Systemic Treatment with Erythropoietin Protects the Neurovascular Unit in a Rat Model of Retinal Neurodegeneration
por: Busch, Stephanie, et al.
Publicado: (2014)

The DPP-4 Inhibitor Linagliptin Counteracts Stroke in the Normal and Diabetic Mouse Brain: A Comparison With Glimepiride
por: Darsalia, Vladimer, et al.
Publicado: (2013)

Glucosamine protects against neuronal but not vascular damage in experimental diabetic retinopathy
por: Eshwaran, Rachana, et al.
Publicado: (2021)

TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation
por: Sachdeva, Robin, et al.
Publicado: (2018)

Protective effect of Soluble Epoxide Hydrolase Inhibition in Retinal Vasculopathy associated with Polycystic Kidney Disease
por: Lin, Jihong, et al.
Publicado: (2020)

Expression patterning reveals retinal inflammation as a minor factor in experimental retinopathy of ZDF rats
por: Wohlfart, Paulus, et al.
Publicado: (2014)

Emerging DPP-4 inhibitors: focus on linagliptin for type 2 diabetes
por: Gallwitz, Baptist
Publicado: (2013)

DPP-4 inhibition with linagliptin ameliorates the progression of premature aging in klotho−/− mice
por: Hasegawa, Yu, et al.
Publicado: (2017)

miRNA-124 Prevents Rat Diabetic Retinopathy by Inhibiting the Microglial Inflammatory Response
por: Chen, Ying, et al.
Publicado: (2023)

Microglial Activation Is Associated With Vasoprotection in a Rat Model of Inflammatory Retinal Vasoregression
por: Riemann, Sarah, et al.
Publicado: (2021)

Type 2 diabetes impairs odour detection, olfactory memory and olfactory neuroplasticity; effects partly reversed by the DPP-4 inhibitor Linagliptin
por: Lietzau, Grazyna, et al.
Publicado: (2018)

Protective Effects of Transient Glucose Exposure in Adult C. elegans
por: Murillo, Katharina, et al.
Publicado: (2022)

Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice
por: McVicar, Carmel M., et al.
Publicado: (2015)

The role of insulin resistance in experimental diabetic retinopathy—Genetic and molecular aspects
por: Järgen, Patrick, et al.
Publicado: (2017)

DPP‐4 Inhibitor Linagliptin Attenuates Aβ‐induced Cytotoxicity through Activation of AMPK in Neuronal Cells
por: Kornelius, Edy, et al.
Publicado: (2015)

SGLT2 Inhibitor Empagliflozin and DPP4 Inhibitor Linagliptin Reactivate Glomerular Autophagy in db/db Mice, a Model of Type 2 Diabetes
por: Korbut, Anton I., et al.
Publicado: (2020)

Linagliptin Improves Insulin Sensitivity and Hepatic Steatosis in Diet-Induced Obesity
por: Kern, Matthias, et al.
Publicado: (2012)

Antioxidant Effects of DPP-4 Inhibitors in Early Stages of Experimental Diabetic Retinopathy
por: Ramos, Hugo, et al.
Publicado: (2022)

DPP-4 Inhibitor Linagliptin Ameliorates Oxidized LDL-Induced THP-1 Macrophage Foam Cell Formation and Inflammation
por: Wang, Haoran, et al.
Publicado: (2020)

DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure
por: Koibuchi, Nobutaka, et al.
Publicado: (2014)

Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice
por: Aroor, Annayya R., et al.
Publicado: (2017)

A comparative study of the binding properties, dipeptidyl peptidase‐4 (DPP‐4) inhibitory activity and glucose‐lowering efficacy of the DPP‐4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice
por: Berger, Joel P., et al.
Publicado: (2017)

DPP-4 inhibition with linagliptin ameliorates cognitive impairment and brain atrophy induced by transient cerebral ischemia in type 2 diabetic mice
por: Ma, MingJie, et al.
Publicado: (2015)

Incorrect description of mode of excretion of linagliptin
por: Woerle, Hans-Juergen, et al.
Publicado: (2010)

Minimum Effective Dose of DPP-4 Inhibitors for Treating Early Stages of Diabetic Retinopathy in an Experimental Model
por: Bogdanov, Patricia, et al.
Publicado: (2022)

Combined treatment with DPP-4 inhibitor linagliptin and SGLT2 inhibitor empagliflozin attenuates neointima formation after vascular injury in diabetic mice
por: Takahashi, Hiroyuki, et al.
Publicado: (2019)

Effects of Linagliptin on Pancreatic α Cells of Type 1 Diabetic Mice
por: Zhang, Yanqing, et al.
Publicado: (2017)

Study Protocol for the Initial Choice of DPP-4 Inhibitor in Japanese Patients with Type 2 diabetes Mellitus: Effect of Linagliptin on QOL (INTEL-QOL) Trial
por: Mita, Tomoya, et al.
Publicado: (2018)

The clinical application of linagliptin in Asians
por: Cao, Chu-qing, et al.
Publicado: (2015)

Linagliptin: from bench to bedside
por: Doupis, John
Publicado: (2014)

Linagliptin prevents left ventricular stiffening by reducing titin cleavage and hypophosphorylation
por: Cuijpers, Ilona, et al.
Publicado: (2020)

Targeting DPP4-RBD interactions by sitagliptin and linagliptin delivers a potential host-directed therapy against pan-SARS-CoV-2 infections
por: Mani, Shailendra, et al.
Publicado: (2023)

Linagliptin Increases Incretin Levels, Lowers Glucagon, and Improves Glycemic Control in Type 2 Diabetes Mellitus
por: Rauch, Thomas, et al.
Publicado: (2012)

Combination of Linagliptin and Metformin for the Treatment of Patients with Type 2 Diabetes
por: Haak, Thomas
Publicado: (2015)

MicroRNA-124 Alleviates Retinal Vasoregression via Regulating Microglial Polarization
por: Chen, Ying, et al.
Publicado: (2021)

Empagliflozin (an SGLT2 inhibitor), alone or in combination with linagliptin (a DPP-4 inhibitor), prevents steatohepatitis in a novel mouse model of non-alcoholic steatohepatitis and diabetes
por: Jojima, Teruo, et al.
Publicado: (2016)

Diabetic Retinopathy: Targeting Vasoregression
por: Hammes, Hans-Peter, et al.
Publicado: (2011)

Acute Kidney Injury Associated with Linagliptin
por: Nandikanti, Deepak K., et al.
Publicado: (2016)

Linagliptin-Associated Alopecia and Bullous Pemphigoid
por: Someili, Ali, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_19r4dljpkmtvahumjds816l6oh