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Cost comparison of treating chronic hepatitis C genotype one with pegylated interferons in Ukraine
Based on the pivotal trial showing no clinically relevant differences between pegylated interferon α-2b (Peg-α-2b) and α-2a (Peg-α-2a) combined with ribavirin for treatment of chronic hepatitis C virus (HCV) genotype 1 infection in Ukraine, a cost-minimization analysis was performed using a 1 year t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter Open
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152959/ https://www.ncbi.nlm.nih.gov/pubmed/28352673 http://dx.doi.org/10.1515/med-2015-0006 |
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author | Mandrik, Olena Knies, Saskia Golubovska, Olha Duda, Oleksandr Dudar, Larisa Fedorchenko, Sergiy Zaliska, Olha (Hans) Severens, J. L. |
author_facet | Mandrik, Olena Knies, Saskia Golubovska, Olha Duda, Oleksandr Dudar, Larisa Fedorchenko, Sergiy Zaliska, Olha (Hans) Severens, J. L. |
author_sort | Mandrik, Olena |
collection | PubMed |
description | Based on the pivotal trial showing no clinically relevant differences between pegylated interferon α-2b (Peg-α-2b) and α-2a (Peg-α-2a) combined with ribavirin for treatment of chronic hepatitis C virus (HCV) genotype 1 infection in Ukraine, a cost-minimization analysis was performed using a 1 year time horizon and both a health care and patients’ perspective. A decision tree reflects treatment pathways. Drug costs were based on drug labeling and adjusted to the average body mass in Ukraine. Subgroup analysis was applied to deal with heterogeneity of patient’s weight causing dose changes. A break-even price of Peg-α-2a and Peg-α-2b (based on the average dose) was calculated. Univariate sensitivity analyses and probabilistic sensitivity analysis were carried out to reflect decision uncertainty. For an average body weight, total medical costs per patient differ from US$9220 for Peg-α-2b to US$9513 for Peg-α-2a from a health care perspective, and from US$15,212 to US$15,696 from a patients’ perspective. Sensitivity analyses show these results are robust. With average body weight, the break-even price of Peg-α-2b may be 7.3% higher than Peg-α-2a to have similar total costs. |
format | Online Article Text |
id | pubmed-5152959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | De Gruyter Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-51529592017-03-28 Cost comparison of treating chronic hepatitis C genotype one with pegylated interferons in Ukraine Mandrik, Olena Knies, Saskia Golubovska, Olha Duda, Oleksandr Dudar, Larisa Fedorchenko, Sergiy Zaliska, Olha (Hans) Severens, J. L. Open Med (Wars) Research Article Based on the pivotal trial showing no clinically relevant differences between pegylated interferon α-2b (Peg-α-2b) and α-2a (Peg-α-2a) combined with ribavirin for treatment of chronic hepatitis C virus (HCV) genotype 1 infection in Ukraine, a cost-minimization analysis was performed using a 1 year time horizon and both a health care and patients’ perspective. A decision tree reflects treatment pathways. Drug costs were based on drug labeling and adjusted to the average body mass in Ukraine. Subgroup analysis was applied to deal with heterogeneity of patient’s weight causing dose changes. A break-even price of Peg-α-2a and Peg-α-2b (based on the average dose) was calculated. Univariate sensitivity analyses and probabilistic sensitivity analysis were carried out to reflect decision uncertainty. For an average body weight, total medical costs per patient differ from US$9220 for Peg-α-2b to US$9513 for Peg-α-2a from a health care perspective, and from US$15,212 to US$15,696 from a patients’ perspective. Sensitivity analyses show these results are robust. With average body weight, the break-even price of Peg-α-2b may be 7.3% higher than Peg-α-2a to have similar total costs. De Gruyter Open 2014-10-08 /pmc/articles/PMC5152959/ /pubmed/28352673 http://dx.doi.org/10.1515/med-2015-0006 Text en © 2015 Olena Mandrik et al http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. |
spellingShingle | Research Article Mandrik, Olena Knies, Saskia Golubovska, Olha Duda, Oleksandr Dudar, Larisa Fedorchenko, Sergiy Zaliska, Olha (Hans) Severens, J. L. Cost comparison of treating chronic hepatitis C genotype one with pegylated interferons in Ukraine |
title | Cost comparison of treating chronic hepatitis C genotype one with pegylated interferons in Ukraine |
title_full | Cost comparison of treating chronic hepatitis C genotype one with pegylated interferons in Ukraine |
title_fullStr | Cost comparison of treating chronic hepatitis C genotype one with pegylated interferons in Ukraine |
title_full_unstemmed | Cost comparison of treating chronic hepatitis C genotype one with pegylated interferons in Ukraine |
title_short | Cost comparison of treating chronic hepatitis C genotype one with pegylated interferons in Ukraine |
title_sort | cost comparison of treating chronic hepatitis c genotype one with pegylated interferons in ukraine |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152959/ https://www.ncbi.nlm.nih.gov/pubmed/28352673 http://dx.doi.org/10.1515/med-2015-0006 |
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