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Use of antiviral therapy in patients with chronic hepatitis C
INTRODUCTION: The presence of background HCV infection cannot be overestimated in view of the prevalence of chronic hepatitis C and the risk of adverse outcomes of this disease. Purpose of this study was to evaluate the effectiveness of the combined use of antiviral therapy (Roferon + Vero-Ribavirin...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter Open
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152973/ https://www.ncbi.nlm.nih.gov/pubmed/28352697 http://dx.doi.org/10.1515/med-2015-0032 |
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author | Dragomiretskaya, Natalia Izha, Anna Kalinichenko, Nikolay Szark-Eckardt, Mirosława Klimczyk, Mariusz Cieślicka, Mirosława Muszkieta, Radosław Prusik, Krzysztof Napierała, Marek Żukowska, Hanna Zukow, Walery |
author_facet | Dragomiretskaya, Natalia Izha, Anna Kalinichenko, Nikolay Szark-Eckardt, Mirosława Klimczyk, Mariusz Cieślicka, Mirosława Muszkieta, Radosław Prusik, Krzysztof Napierała, Marek Żukowska, Hanna Zukow, Walery |
author_sort | Dragomiretskaya, Natalia |
collection | PubMed |
description | INTRODUCTION: The presence of background HCV infection cannot be overestimated in view of the prevalence of chronic hepatitis C and the risk of adverse outcomes of this disease. Purpose of this study was to evaluate the effectiveness of the combined use of antiviral therapy (Roferon + Vero-Ribavirin) and resort factors in patients with chronic hepatitis C in the phase of replication. MATERIAL AND METHODS: We observed 48 patients with chronic hepatitis C; the minimum level of activity of the process defined the phase of replication. Markers of HCV infection were determined by enzyme linked immunosorbent assay (ELISA) (a-HCV and HCV-Ig M). HCV RNA was determined twice by the polymerase chain reaction (PCR). Genotyping of hepatitis C virus was performed. Biochemical blood analysis and the study of HCV infection markers were carried out four times. Results of therapy were assessed immediately after the end of the resort (spa) treatment, then at 3, 6 and 12 months after starting treatment. At 12 months after starting treatment, all the observed patients had persistent clinical and biochemical remission. Elimination of the virus from the blood was noted in 56% of the control group and 74% of patients in the study group. CONCLUSIONS: For patients with moderately active HCV, the replication phase was characterized by asthenic-vegetative syndrome (100% of patients) with severe depression (22.92%), pain (77.08%) and dyspeptic syndrome (33.33%), moderate hypertransferaseemia (100%), slightly pronounced cholestasis (33% of patients), and signs of mesenchymal-inflammatory response. |
format | Online Article Text |
id | pubmed-5152973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | De Gruyter Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-51529732017-03-28 Use of antiviral therapy in patients with chronic hepatitis C Dragomiretskaya, Natalia Izha, Anna Kalinichenko, Nikolay Szark-Eckardt, Mirosława Klimczyk, Mariusz Cieślicka, Mirosława Muszkieta, Radosław Prusik, Krzysztof Napierała, Marek Żukowska, Hanna Zukow, Walery Open Med (Wars) Research Article INTRODUCTION: The presence of background HCV infection cannot be overestimated in view of the prevalence of chronic hepatitis C and the risk of adverse outcomes of this disease. Purpose of this study was to evaluate the effectiveness of the combined use of antiviral therapy (Roferon + Vero-Ribavirin) and resort factors in patients with chronic hepatitis C in the phase of replication. MATERIAL AND METHODS: We observed 48 patients with chronic hepatitis C; the minimum level of activity of the process defined the phase of replication. Markers of HCV infection were determined by enzyme linked immunosorbent assay (ELISA) (a-HCV and HCV-Ig M). HCV RNA was determined twice by the polymerase chain reaction (PCR). Genotyping of hepatitis C virus was performed. Biochemical blood analysis and the study of HCV infection markers were carried out four times. Results of therapy were assessed immediately after the end of the resort (spa) treatment, then at 3, 6 and 12 months after starting treatment. At 12 months after starting treatment, all the observed patients had persistent clinical and biochemical remission. Elimination of the virus from the blood was noted in 56% of the control group and 74% of patients in the study group. CONCLUSIONS: For patients with moderately active HCV, the replication phase was characterized by asthenic-vegetative syndrome (100% of patients) with severe depression (22.92%), pain (77.08%) and dyspeptic syndrome (33.33%), moderate hypertransferaseemia (100%), slightly pronounced cholestasis (33% of patients), and signs of mesenchymal-inflammatory response. De Gruyter Open 2015-03-20 /pmc/articles/PMC5152973/ /pubmed/28352697 http://dx.doi.org/10.1515/med-2015-0032 Text en © 2015 Walery Zukow et al http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. |
spellingShingle | Research Article Dragomiretskaya, Natalia Izha, Anna Kalinichenko, Nikolay Szark-Eckardt, Mirosława Klimczyk, Mariusz Cieślicka, Mirosława Muszkieta, Radosław Prusik, Krzysztof Napierała, Marek Żukowska, Hanna Zukow, Walery Use of antiviral therapy in patients with chronic hepatitis C |
title | Use of antiviral therapy in patients with chronic hepatitis C |
title_full | Use of antiviral therapy in patients with chronic hepatitis C |
title_fullStr | Use of antiviral therapy in patients with chronic hepatitis C |
title_full_unstemmed | Use of antiviral therapy in patients with chronic hepatitis C |
title_short | Use of antiviral therapy in patients with chronic hepatitis C |
title_sort | use of antiviral therapy in patients with chronic hepatitis c |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152973/ https://www.ncbi.nlm.nih.gov/pubmed/28352697 http://dx.doi.org/10.1515/med-2015-0032 |
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