The latent cytomegalovirus decreases telomere length by microcompetition

Reduced telomere length has been associated with aging and age-related diseases. Latent infection with the Cytomegalovirus (CMV) induces telomere shortening in the infected cells. Latent CMV infection may cause reduced telomere length via GABP transcription factor deficiency, according to the Microc...

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Detalles Bibliográficos
Autores principales: Polansky, Hanan, Javaherian, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter Open 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152988/
https://www.ncbi.nlm.nih.gov/pubmed/28352708
http://dx.doi.org/10.1515/med-2015-0042
Descripción
Sumario:Reduced telomere length has been associated with aging and age-related diseases. Latent infection with the Cytomegalovirus (CMV) induces telomere shortening in the infected cells. Latent CMV infection may cause reduced telomere length via GABP transcription factor deficiency, according to the Microcompetition Theory. Microcompetition and viral-induced transcription factor deficiency is important since most people harbor a latent viral infection.

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