Cargando…
Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex
Eukaryotic translation initiation factor 3 (eIF3) is a central player in recruitment of the pre-initiation complex (PIC) to mRNA. We probed the effects on mRNA recruitment of a library of S. cerevisiae eIF3 functional variants spanning its 5 essential subunits using an in vitro-reconstituted system....
Autores principales: | Aitken, Colin Echeverría, Beznosková, Petra, Vlčkova, Vladislava, Chiu, Wen-Ling, Zhou, Fujun, Valášek, Leoš Shivaya, Hinnebusch, Alan G, Lorsch, Jon R |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153249/ https://www.ncbi.nlm.nih.gov/pubmed/27782884 http://dx.doi.org/10.7554/eLife.20934 |
Ejemplares similares
-
An emergency brake for protein synthesis
por: Hronová, Vladislava, et al.
Publicado: (2017) -
In-depth analysis of cis-determinants that either promote or inhibit reinitiation on GCN4 mRNA after translation of its four short uORFs
por: Gunišová, Stanislava, et al.
Publicado: (2016) -
Please do not recycle! Translation reinitiation in microbes and higher eukaryotes
por: Gunišová, Stanislava, et al.
Publicado: (2017) -
‘Ribozoomin’ – Translation Initiation from the Perspective of the Ribosome-bound Eukaryotic Initiation Factors (eIFs)
por: Valášek, Leoš Shivaya
Publicado: (2012) -
Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes
por: Khoshnevis, Sohail, et al.
Publicado: (2014)