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Biomechanical and histological evaluation of the osseointegration capacity of two types of zirconia implant
The purpose of this study was to evaluate the biomechanical and histological behavior of a ceria-stabilized zirconia–alumina nanocomposite (NanoZr) in comparison with that of 3 mol% yttria-stabilized tetragonal zirconia polycrystalline (3Y-TZP) in Sprague Dawley rats. Cylindrical NanoZr and 3Y-TZP i...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153287/ https://www.ncbi.nlm.nih.gov/pubmed/27994456 http://dx.doi.org/10.2147/IJN.S119519 |
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author | Han, Jian-min Hong, Guang Lin, Hong Shimizu, Yoshinaka Wu, Yuhan Zheng, Gang Zhang, Hongyu Sasaki, Keiichi |
author_facet | Han, Jian-min Hong, Guang Lin, Hong Shimizu, Yoshinaka Wu, Yuhan Zheng, Gang Zhang, Hongyu Sasaki, Keiichi |
author_sort | Han, Jian-min |
collection | PubMed |
description | The purpose of this study was to evaluate the biomechanical and histological behavior of a ceria-stabilized zirconia–alumina nanocomposite (NanoZr) in comparison with that of 3 mol% yttria-stabilized tetragonal zirconia polycrystalline (3Y-TZP) in Sprague Dawley rats. Cylindrical NanoZr and 3Y-TZP implants (diameter 1 mm, length 2 mm) were used. Implant-surface morphology and surface roughness were determined by scanning white-light interferometry and scanning electron microscopy, respectively. The cylindrical zirconia implants were placed at the distal edge of the femur of Sprague Dawley rats. At weeks 2, 4, and 8, the interfacial shear strength between implant and bone was measured by push-in test. Histological analysis was performed using hard-tissue sections. Bone–implant contact (BIC), the thickness of new bone around the implant within the bone marrow area, and osteoclast numbers were evaluated. The average surface roughness of 3Y-TZP (Sa 0.788 μm) was significantly higher than that of NanoZr (Sa 0.559 μm). The shear strengths of 3Y-TZP and NanoZr were similar at 2 weeks, but at 4 and 8 weeks the shear strength of NanoZr was higher than that of 3Y-TZP. The average BIC values within the bone marrow area for 3Y-TZP and NanoZr were 25.26% and 31.51% at 2 weeks, 46.78% and 38% at 4 weeks, and 47.88% and 56.81% at 8 weeks, respectively. The average BIC values within the cortical area were 38.86% and 58.42% at 2 weeks, 66.82% and 57.74% at 4 weeks, and 79.91% and 78.97% at 8 weeks, respectively. The mean BIC value did not differ significantly between the two zirconia materials at any time point. The NanoZr implants were biocompatible, capable of establishing close BIC, and may be preferred for metal-free dental implants. |
format | Online Article Text |
id | pubmed-5153287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-51532872016-12-19 Biomechanical and histological evaluation of the osseointegration capacity of two types of zirconia implant Han, Jian-min Hong, Guang Lin, Hong Shimizu, Yoshinaka Wu, Yuhan Zheng, Gang Zhang, Hongyu Sasaki, Keiichi Int J Nanomedicine Original Research The purpose of this study was to evaluate the biomechanical and histological behavior of a ceria-stabilized zirconia–alumina nanocomposite (NanoZr) in comparison with that of 3 mol% yttria-stabilized tetragonal zirconia polycrystalline (3Y-TZP) in Sprague Dawley rats. Cylindrical NanoZr and 3Y-TZP implants (diameter 1 mm, length 2 mm) were used. Implant-surface morphology and surface roughness were determined by scanning white-light interferometry and scanning electron microscopy, respectively. The cylindrical zirconia implants were placed at the distal edge of the femur of Sprague Dawley rats. At weeks 2, 4, and 8, the interfacial shear strength between implant and bone was measured by push-in test. Histological analysis was performed using hard-tissue sections. Bone–implant contact (BIC), the thickness of new bone around the implant within the bone marrow area, and osteoclast numbers were evaluated. The average surface roughness of 3Y-TZP (Sa 0.788 μm) was significantly higher than that of NanoZr (Sa 0.559 μm). The shear strengths of 3Y-TZP and NanoZr were similar at 2 weeks, but at 4 and 8 weeks the shear strength of NanoZr was higher than that of 3Y-TZP. The average BIC values within the bone marrow area for 3Y-TZP and NanoZr were 25.26% and 31.51% at 2 weeks, 46.78% and 38% at 4 weeks, and 47.88% and 56.81% at 8 weeks, respectively. The average BIC values within the cortical area were 38.86% and 58.42% at 2 weeks, 66.82% and 57.74% at 4 weeks, and 79.91% and 78.97% at 8 weeks, respectively. The mean BIC value did not differ significantly between the two zirconia materials at any time point. The NanoZr implants were biocompatible, capable of establishing close BIC, and may be preferred for metal-free dental implants. Dove Medical Press 2016-12-07 /pmc/articles/PMC5153287/ /pubmed/27994456 http://dx.doi.org/10.2147/IJN.S119519 Text en © 2016 Han et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Han, Jian-min Hong, Guang Lin, Hong Shimizu, Yoshinaka Wu, Yuhan Zheng, Gang Zhang, Hongyu Sasaki, Keiichi Biomechanical and histological evaluation of the osseointegration capacity of two types of zirconia implant |
title | Biomechanical and histological evaluation of the osseointegration capacity of two types of zirconia implant |
title_full | Biomechanical and histological evaluation of the osseointegration capacity of two types of zirconia implant |
title_fullStr | Biomechanical and histological evaluation of the osseointegration capacity of two types of zirconia implant |
title_full_unstemmed | Biomechanical and histological evaluation of the osseointegration capacity of two types of zirconia implant |
title_short | Biomechanical and histological evaluation of the osseointegration capacity of two types of zirconia implant |
title_sort | biomechanical and histological evaluation of the osseointegration capacity of two types of zirconia implant |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153287/ https://www.ncbi.nlm.nih.gov/pubmed/27994456 http://dx.doi.org/10.2147/IJN.S119519 |
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