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Thyroid hormone dysfunction during pregnancy: A review

Thyroid dysfunctions such as hypothyroidism, thyrotoxicosis and thyroid nodules may develop during pregnancy leading to abortion, placental abruptions, preeclampsia, preterm delivery and reduced intellectual function in the offspring. Epidemiological data have shown the significant role of maternal...

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Autores principales: Alemu, Aynadis, Terefe, Betelihem, Abebe, Molla, Biadgo, Belete
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research and Clinical Center for Infertility 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153572/
https://www.ncbi.nlm.nih.gov/pubmed/27981252
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author Alemu, Aynadis
Terefe, Betelihem
Abebe, Molla
Biadgo, Belete
author_facet Alemu, Aynadis
Terefe, Betelihem
Abebe, Molla
Biadgo, Belete
author_sort Alemu, Aynadis
collection PubMed
description Thyroid dysfunctions such as hypothyroidism, thyrotoxicosis and thyroid nodules may develop during pregnancy leading to abortion, placental abruptions, preeclampsia, preterm delivery and reduced intellectual function in the offspring. Epidemiological data have shown the significant role of maternal thyroid hormone in fetal neurologic development and maternal health. It has been suggested that the deleterious effects of thyroid dysfunction can also extend beyond pregnancy and delivery to affect neuro-intellectual development in the early life of the child. Pregnancy poses an important challenge to the maternal thyroid gland as hormone requirements are increased during gestation as a result of an increase in thyroid- binding globulin, the stimulatory effect of HCG on TSH receptors, and increased peripheral thyroid hormone requirements. Maternal thyroid dysfunction is associated with increased risk for early abortion, preterm delivery, neonatal morbidity and other obstetrical complications. Early diagnosis for thyroid dysfunction of pregnant women and treatment of thyroid dysfunction during pregnancy is important and cost effective to avoid both fetal and maternal complications secondary to thyroid dysfunction. Therefore the aim of this review was to assess the thyroid function changes occurring during pregnancy, the different disorders with their maternal and fetal implications, the laboratory diagnosis and the best ways of management of these conditions.
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spelling pubmed-51535722016-12-15 Thyroid hormone dysfunction during pregnancy: A review Alemu, Aynadis Terefe, Betelihem Abebe, Molla Biadgo, Belete Int J Reprod Biomed Review Article Thyroid dysfunctions such as hypothyroidism, thyrotoxicosis and thyroid nodules may develop during pregnancy leading to abortion, placental abruptions, preeclampsia, preterm delivery and reduced intellectual function in the offspring. Epidemiological data have shown the significant role of maternal thyroid hormone in fetal neurologic development and maternal health. It has been suggested that the deleterious effects of thyroid dysfunction can also extend beyond pregnancy and delivery to affect neuro-intellectual development in the early life of the child. Pregnancy poses an important challenge to the maternal thyroid gland as hormone requirements are increased during gestation as a result of an increase in thyroid- binding globulin, the stimulatory effect of HCG on TSH receptors, and increased peripheral thyroid hormone requirements. Maternal thyroid dysfunction is associated with increased risk for early abortion, preterm delivery, neonatal morbidity and other obstetrical complications. Early diagnosis for thyroid dysfunction of pregnant women and treatment of thyroid dysfunction during pregnancy is important and cost effective to avoid both fetal and maternal complications secondary to thyroid dysfunction. Therefore the aim of this review was to assess the thyroid function changes occurring during pregnancy, the different disorders with their maternal and fetal implications, the laboratory diagnosis and the best ways of management of these conditions. Research and Clinical Center for Infertility 2016-11 /pmc/articles/PMC5153572/ /pubmed/27981252 Text en http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Alemu, Aynadis
Terefe, Betelihem
Abebe, Molla
Biadgo, Belete
Thyroid hormone dysfunction during pregnancy: A review
title Thyroid hormone dysfunction during pregnancy: A review
title_full Thyroid hormone dysfunction during pregnancy: A review
title_fullStr Thyroid hormone dysfunction during pregnancy: A review
title_full_unstemmed Thyroid hormone dysfunction during pregnancy: A review
title_short Thyroid hormone dysfunction during pregnancy: A review
title_sort thyroid hormone dysfunction during pregnancy: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153572/
https://www.ncbi.nlm.nih.gov/pubmed/27981252
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