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Hypogonadism alters cecal and fecal microbiota in male mice

Low testosterone levels increase the risk for cardiovascular disease in men and lead to shorter life spans. Our recent study showed that androgen deprivation via castration altered fecal microbiota and exacerbated risk factors for cardiovascular disease, including obesity, impaired fasting glucose,...

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Detalles Bibliográficos
Autores principales: Harada, Naoki, Hanaoka, Ryo, Hanada, Kazuki, Izawa, Takeshi, Inui, Hiroshi, Yamaji, Ryoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153613/
https://www.ncbi.nlm.nih.gov/pubmed/27656762
http://dx.doi.org/10.1080/19490976.2016.1239680
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author Harada, Naoki
Hanaoka, Ryo
Hanada, Kazuki
Izawa, Takeshi
Inui, Hiroshi
Yamaji, Ryoichi
author_facet Harada, Naoki
Hanaoka, Ryo
Hanada, Kazuki
Izawa, Takeshi
Inui, Hiroshi
Yamaji, Ryoichi
author_sort Harada, Naoki
collection PubMed
description Low testosterone levels increase the risk for cardiovascular disease in men and lead to shorter life spans. Our recent study showed that androgen deprivation via castration altered fecal microbiota and exacerbated risk factors for cardiovascular disease, including obesity, impaired fasting glucose, excess hepatic triglyceride accumulation, and thigh muscle weight loss only in high-fat diet (HFD)-fed male mice. However, when mice were administered antibiotics that disrupted the gut microbiota, castration did not increase cardiovascular risks or decrease the ratio of dried feces to food intake. Here, we show that changes in cecal microbiota (e.g., an increased Firmicutes/Bacteroidetes ratio and number of Lactobacillus species) were consistent with changes in feces and that there was a decreased cecal content secondary to castration in HFD mice. Castration increased rectal body temperature and plasma adiponectin, irrespective of diet. Changes in the gut microbiome may provide novel insight into hypogonadism-induced cardiovascular diseases.
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spelling pubmed-51536132016-12-21 Hypogonadism alters cecal and fecal microbiota in male mice Harada, Naoki Hanaoka, Ryo Hanada, Kazuki Izawa, Takeshi Inui, Hiroshi Yamaji, Ryoichi Gut Microbes Addendum Low testosterone levels increase the risk for cardiovascular disease in men and lead to shorter life spans. Our recent study showed that androgen deprivation via castration altered fecal microbiota and exacerbated risk factors for cardiovascular disease, including obesity, impaired fasting glucose, excess hepatic triglyceride accumulation, and thigh muscle weight loss only in high-fat diet (HFD)-fed male mice. However, when mice were administered antibiotics that disrupted the gut microbiota, castration did not increase cardiovascular risks or decrease the ratio of dried feces to food intake. Here, we show that changes in cecal microbiota (e.g., an increased Firmicutes/Bacteroidetes ratio and number of Lactobacillus species) were consistent with changes in feces and that there was a decreased cecal content secondary to castration in HFD mice. Castration increased rectal body temperature and plasma adiponectin, irrespective of diet. Changes in the gut microbiome may provide novel insight into hypogonadism-induced cardiovascular diseases. Taylor & Francis 2016-09-22 /pmc/articles/PMC5153613/ /pubmed/27656762 http://dx.doi.org/10.1080/19490976.2016.1239680 Text en © 2016 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Addendum
Harada, Naoki
Hanaoka, Ryo
Hanada, Kazuki
Izawa, Takeshi
Inui, Hiroshi
Yamaji, Ryoichi
Hypogonadism alters cecal and fecal microbiota in male mice
title Hypogonadism alters cecal and fecal microbiota in male mice
title_full Hypogonadism alters cecal and fecal microbiota in male mice
title_fullStr Hypogonadism alters cecal and fecal microbiota in male mice
title_full_unstemmed Hypogonadism alters cecal and fecal microbiota in male mice
title_short Hypogonadism alters cecal and fecal microbiota in male mice
title_sort hypogonadism alters cecal and fecal microbiota in male mice
topic Addendum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153613/
https://www.ncbi.nlm.nih.gov/pubmed/27656762
http://dx.doi.org/10.1080/19490976.2016.1239680
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