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Improved genome-scale multi-target virtual screening via a novel collaborative filtering approach to cold-start problem
Conventional one-drug-one-gene approach has been of limited success in modern drug discovery. Polypharmacology, which focuses on searching for multi-targeted drugs to perturb disease-causing networks instead of designing selective ligands to target individual proteins, has emerged as a new drug disc...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153628/ https://www.ncbi.nlm.nih.gov/pubmed/27958331 http://dx.doi.org/10.1038/srep38860 |