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Global map of oxytocin/vasopressin-like neuropeptide signalling in insects
Oxytocin and vasopressin mediate a range of physiological functions that are important for osmoregulation, reproduction, social behaviour, memory and learning. The origin of this signalling system is thought to date back ~600 million years. Oxytocin/vasopressin-like peptides have been identified in...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153645/ https://www.ncbi.nlm.nih.gov/pubmed/27958372 http://dx.doi.org/10.1038/srep39177 |
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author | Liutkeviciute, Zita Koehbach, Johannes Eder, Thomas Gil-Mansilla, Esther Gruber, Christian W. |
author_facet | Liutkeviciute, Zita Koehbach, Johannes Eder, Thomas Gil-Mansilla, Esther Gruber, Christian W. |
author_sort | Liutkeviciute, Zita |
collection | PubMed |
description | Oxytocin and vasopressin mediate a range of physiological functions that are important for osmoregulation, reproduction, social behaviour, memory and learning. The origin of this signalling system is thought to date back ~600 million years. Oxytocin/vasopressin-like peptides have been identified in several invertebrate species and they appear to be functionally related across the entire animal kingdom. There is little information available about the biology of this peptide G protein-coupled receptor signalling system in insects. Recently over 200 insect genome/transcriptome datasets were released allowing investigation of the molecular structure and phylogenetic distribution of the insect oxytocin/vasopressin orthologue – inotocin peptides and their receptors. The signalling system is present in early arthropods and representatives of some early-diverging lineages. However, Trichoptera, Lepidoptera, Siphonaptera, Mecoptera and Diptera, lack the presence of inotocin genes, which suggests the peptide-receptor system was probably lost in their common ancestor ~280 million-years-ago. In addition we detected several losses of the inotocin signalling system in Hemiptera (white flies, scale insects and aphids), and the complete absence in spiders (Chelicerata). This unique insight into evolutionarily patterns and sequence diversity of neuroendocrine hormones will provide opportunities to elucidate the physiology of the inotocin signalling system in one of the largest group of animals. |
format | Online Article Text |
id | pubmed-5153645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51536452016-12-28 Global map of oxytocin/vasopressin-like neuropeptide signalling in insects Liutkeviciute, Zita Koehbach, Johannes Eder, Thomas Gil-Mansilla, Esther Gruber, Christian W. Sci Rep Article Oxytocin and vasopressin mediate a range of physiological functions that are important for osmoregulation, reproduction, social behaviour, memory and learning. The origin of this signalling system is thought to date back ~600 million years. Oxytocin/vasopressin-like peptides have been identified in several invertebrate species and they appear to be functionally related across the entire animal kingdom. There is little information available about the biology of this peptide G protein-coupled receptor signalling system in insects. Recently over 200 insect genome/transcriptome datasets were released allowing investigation of the molecular structure and phylogenetic distribution of the insect oxytocin/vasopressin orthologue – inotocin peptides and their receptors. The signalling system is present in early arthropods and representatives of some early-diverging lineages. However, Trichoptera, Lepidoptera, Siphonaptera, Mecoptera and Diptera, lack the presence of inotocin genes, which suggests the peptide-receptor system was probably lost in their common ancestor ~280 million-years-ago. In addition we detected several losses of the inotocin signalling system in Hemiptera (white flies, scale insects and aphids), and the complete absence in spiders (Chelicerata). This unique insight into evolutionarily patterns and sequence diversity of neuroendocrine hormones will provide opportunities to elucidate the physiology of the inotocin signalling system in one of the largest group of animals. Nature Publishing Group 2016-12-13 /pmc/articles/PMC5153645/ /pubmed/27958372 http://dx.doi.org/10.1038/srep39177 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Liutkeviciute, Zita Koehbach, Johannes Eder, Thomas Gil-Mansilla, Esther Gruber, Christian W. Global map of oxytocin/vasopressin-like neuropeptide signalling in insects |
title | Global map of oxytocin/vasopressin-like neuropeptide signalling in insects |
title_full | Global map of oxytocin/vasopressin-like neuropeptide signalling in insects |
title_fullStr | Global map of oxytocin/vasopressin-like neuropeptide signalling in insects |
title_full_unstemmed | Global map of oxytocin/vasopressin-like neuropeptide signalling in insects |
title_short | Global map of oxytocin/vasopressin-like neuropeptide signalling in insects |
title_sort | global map of oxytocin/vasopressin-like neuropeptide signalling in insects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153645/ https://www.ncbi.nlm.nih.gov/pubmed/27958372 http://dx.doi.org/10.1038/srep39177 |
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