Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis

BACKGROUND: SAG (Sensitive to Apoptosis Gene), also known as RBX2, ROC2 or RNF7, is a RING component of CRL (Cullin-RING ligase), required for its activity. Our recent study showed that SAG/RBX2 co-operated with Kras to promote lung tumorigenesis, but antagonized Kras to inhibit skin tumorigenesis,...

Descripción completa

Detalles Bibliográficos
Autores principales: Tan, Mingjia, Xu, Jie, Siddiqui, Javed, Feng, Felix, Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153812/
https://www.ncbi.nlm.nih.gov/pubmed/27955654
http://dx.doi.org/10.1186/s12943-016-0567-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153812/
https://www.ncbi.nlm.nih.gov/pubmed/27955654
http://dx.doi.org/10.1186/s12943-016-0567-6

Ejemplares similares