Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?

When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to ne...

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Autores principales: Bruyneel, Arne A. N., Sehgal, Apurv, Malandraki-Miller, Sophia, Carr, Carolyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153828/
https://www.ncbi.nlm.nih.gov/pubmed/27542008
http://dx.doi.org/10.1007/s12265-016-9708-y
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author Bruyneel, Arne A. N.
Sehgal, Apurv
Malandraki-Miller, Sophia
Carr, Carolyn
author_facet Bruyneel, Arne A. N.
Sehgal, Apurv
Malandraki-Miller, Sophia
Carr, Carolyn
author_sort Bruyneel, Arne A. N.
collection PubMed
description When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to new cardiomyocytes and vasculature. Unfortunately, the results from clinical trials to date have been largely disappointing. In this review, we discuss the current status of the field and describe various limitations and how future work may attempt to resolve these to make way to successful clinical translation.
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spelling pubmed-51538282016-12-27 Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet? Bruyneel, Arne A. N. Sehgal, Apurv Malandraki-Miller, Sophia Carr, Carolyn J Cardiovasc Transl Res Review When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to new cardiomyocytes and vasculature. Unfortunately, the results from clinical trials to date have been largely disappointing. In this review, we discuss the current status of the field and describe various limitations and how future work may attempt to resolve these to make way to successful clinical translation. Springer US 2016-08-19 2016 /pmc/articles/PMC5153828/ /pubmed/27542008 http://dx.doi.org/10.1007/s12265-016-9708-y Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Bruyneel, Arne A. N.
Sehgal, Apurv
Malandraki-Miller, Sophia
Carr, Carolyn
Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?
title Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?
title_full Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?
title_fullStr Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?
title_full_unstemmed Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?
title_short Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?
title_sort stem cell therapy for the heart: blind alley or magic bullet?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153828/
https://www.ncbi.nlm.nih.gov/pubmed/27542008
http://dx.doi.org/10.1007/s12265-016-9708-y
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