Engineering Aspergillus niger for galactaric acid production: elimination of galactaric acid catabolism by using RNA sequencing and CRISPR/Cas9

BACKGROUND: meso-Galactaric acid is a dicarboxylic acid that can be produced by the oxidation of d-galacturonic acid, the main constituent of pectin. Mould strains can be engineered to perform this oxidation by expressing the bacterial enzyme uronate dehydrogenase. In addition, the endogenous pathwa...

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Detalles Bibliográficos
Autores principales: Kuivanen, Joosu, Wang, Y.-M. Jasmin, Richard, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153877/
https://www.ncbi.nlm.nih.gov/pubmed/27955649
http://dx.doi.org/10.1186/s12934-016-0613-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153877/
https://www.ncbi.nlm.nih.gov/pubmed/27955649
http://dx.doi.org/10.1186/s12934-016-0613-5

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