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Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice
CONTEXT: Anxiety disorders are chronic, common, and often comorbid. There is an unmet need in its treatment. Aripiprazole and hydroxyzine are well-known therapeutic options used as monotherapy in clinics. They have different mechanisms and site of actions. AIM: The objective of the present study was...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153890/ https://www.ncbi.nlm.nih.gov/pubmed/27999468 http://dx.doi.org/10.4103/0976-0105.189429 |
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author | Sawantdesai, Nikita Shekhar Kale, Pravin Popatrao Savai, Jay |
author_facet | Sawantdesai, Nikita Shekhar Kale, Pravin Popatrao Savai, Jay |
author_sort | Sawantdesai, Nikita Shekhar |
collection | PubMed |
description | CONTEXT: Anxiety disorders are chronic, common, and often comorbid. There is an unmet need in its treatment. Aripiprazole and hydroxyzine are well-known therapeutic options used as monotherapy in clinics. They have different mechanisms and site of actions. AIM: The objective of the present study was to evaluate the anxiolytic effect of aripiprazole and hydroxyzine in combination. MATERIALS AND METHODS: Swiss albino mice (male) received treatment of 5% of Tween 80 in 0.9% saline (10 ml/kg; control group), “aripiprazole alone” (1 mg/kg), “hydroxyzine alone” (3 mg/kg), and aripiprazole (0.5 mg/kg) + hydroxyzine (1.5 mg/kg) through the intraperitoneal route. RESULTS: The in vivo outcomes (elevated plus maze, light/dark transition, and marble burying tests) of hydroxyzine monotherapy-treated group showed a significant anxiolytic activity. The combination-treated group was found to be better than control and aripiprazole-treated groups. The combination-treated group showed a significant increase in the level of serotonin in different brain regions as compared to aripiprazole-treated group but not better than the hydroxyzine group. The in vitro results were in compliance with the in vivo results. The combinational approach was found to be beneficial in anxiolytic treatment as compared to aripiprazole monotherapy. However, hydroxyzine showed better anxiolytic activity when compared to control, aripiprazole monotherapy, and combination groups. CONCLUSIONS: The anxiolytic effect of combination-treated group was found to be better than aripiprazole monotherapy and lesser than hydroxyzine monotherapy. |
format | Online Article Text |
id | pubmed-5153890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-51538902016-12-20 Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice Sawantdesai, Nikita Shekhar Kale, Pravin Popatrao Savai, Jay J Basic Clin Pharm Original Article CONTEXT: Anxiety disorders are chronic, common, and often comorbid. There is an unmet need in its treatment. Aripiprazole and hydroxyzine are well-known therapeutic options used as monotherapy in clinics. They have different mechanisms and site of actions. AIM: The objective of the present study was to evaluate the anxiolytic effect of aripiprazole and hydroxyzine in combination. MATERIALS AND METHODS: Swiss albino mice (male) received treatment of 5% of Tween 80 in 0.9% saline (10 ml/kg; control group), “aripiprazole alone” (1 mg/kg), “hydroxyzine alone” (3 mg/kg), and aripiprazole (0.5 mg/kg) + hydroxyzine (1.5 mg/kg) through the intraperitoneal route. RESULTS: The in vivo outcomes (elevated plus maze, light/dark transition, and marble burying tests) of hydroxyzine monotherapy-treated group showed a significant anxiolytic activity. The combination-treated group was found to be better than control and aripiprazole-treated groups. The combination-treated group showed a significant increase in the level of serotonin in different brain regions as compared to aripiprazole-treated group but not better than the hydroxyzine group. The in vitro results were in compliance with the in vivo results. The combinational approach was found to be beneficial in anxiolytic treatment as compared to aripiprazole monotherapy. However, hydroxyzine showed better anxiolytic activity when compared to control, aripiprazole monotherapy, and combination groups. CONCLUSIONS: The anxiolytic effect of combination-treated group was found to be better than aripiprazole monotherapy and lesser than hydroxyzine monotherapy. Medknow Publications & Media Pvt Ltd 2016-09 /pmc/articles/PMC5153890/ /pubmed/27999468 http://dx.doi.org/10.4103/0976-0105.189429 Text en Copyright: © Journal of Basic and Clinical Pharmacy http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Sawantdesai, Nikita Shekhar Kale, Pravin Popatrao Savai, Jay Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice |
title | Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice |
title_full | Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice |
title_fullStr | Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice |
title_full_unstemmed | Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice |
title_short | Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice |
title_sort | evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153890/ https://www.ncbi.nlm.nih.gov/pubmed/27999468 http://dx.doi.org/10.4103/0976-0105.189429 |
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