Cargando…

The characteristics of patients with mycobacterium tuberculosis blood stream infections in Beijing, China: a retrospective study

BACKGROUND: Published information regarding the clinical characteristics, laboratory findings, and outcomes of patients with Mycobacterium tuberculosis (MTB) blood stream infection (BSI) is limited. We aimed in this study to evaluate the clinical characteristics, laboratory evaluation, and outcomes...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xiaoqing, Bian, Sainan, Zhang, Yueqiu, Zhang, Lifan, Yang, Qiwen, Wang, Peng, Xu, Yingchun, Shi, Xiaochun, Zhang, Yao, Chemaly, Roy F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153903/
https://www.ncbi.nlm.nih.gov/pubmed/27955709
http://dx.doi.org/10.1186/s12879-016-2084-z
_version_ 1782474788161191936
author Liu, Xiaoqing
Bian, Sainan
Zhang, Yueqiu
Zhang, Lifan
Yang, Qiwen
Wang, Peng
Xu, Yingchun
Shi, Xiaochun
Zhang, Yao
Chemaly, Roy F.
author_facet Liu, Xiaoqing
Bian, Sainan
Zhang, Yueqiu
Zhang, Lifan
Yang, Qiwen
Wang, Peng
Xu, Yingchun
Shi, Xiaochun
Zhang, Yao
Chemaly, Roy F.
author_sort Liu, Xiaoqing
collection PubMed
description BACKGROUND: Published information regarding the clinical characteristics, laboratory findings, and outcomes of patients with Mycobacterium tuberculosis (MTB) blood stream infection (BSI) is limited. We aimed in this study to evaluate the clinical characteristics, laboratory evaluation, and outcomes of patients with MTB BSI. METHODS: All patients diagnosed with MTB BSI at Peking Union Medical College Hospital between January 2008 and May 2014 were identified by examining the electronic database listing results of all blood cultures. Data on demographics, clinical characteristics, laboratory manifestations, management, and outcomes were abstracted from medical records. RESULTS: Six thousand nine hundred seventy-four patients had mycobacterial blood cultures during the study period. Of 48 patients (0.7%) with MTB BSI, 26 patients (54%) were considered to be immunocompromised (refers to a person who has a significantly impaired immune system). This was due to human immunodeficiency virus (HIV) infection (n = 2 of 48 tested), receiving steroids (n = 17, including 16 with rheumatic diseases and one with myasthenia gravis), malignancy (n = 3), diabetes mellitus (n = 3), and renal transplantation (n = 1). The main clinical manifestations were fever (100%, with a median of 40 °C), weight loss (48%) and cough with sputum production (46%). Most patients had one or more organs involved (81%). The median time from onset of fever to diagnosis was 8 weeks (IQR 5 ~ 14). Six patients died within 1 week after diagnosis. Of the 17 patients completing treatment, 14 patients (82%) recovered without major complications and they had a shorter time interval between onsets of symptoms to treatment compared to those died of TB. CONCLUSIONS: In this group of patients with MTB BSI, fever and multiple organs involvement were common, the outcome was poor and timely diagnosis and treatment might favor outcome.
format Online
Article
Text
id pubmed-5153903
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-51539032016-12-20 The characteristics of patients with mycobacterium tuberculosis blood stream infections in Beijing, China: a retrospective study Liu, Xiaoqing Bian, Sainan Zhang, Yueqiu Zhang, Lifan Yang, Qiwen Wang, Peng Xu, Yingchun Shi, Xiaochun Zhang, Yao Chemaly, Roy F. BMC Infect Dis Research Article BACKGROUND: Published information regarding the clinical characteristics, laboratory findings, and outcomes of patients with Mycobacterium tuberculosis (MTB) blood stream infection (BSI) is limited. We aimed in this study to evaluate the clinical characteristics, laboratory evaluation, and outcomes of patients with MTB BSI. METHODS: All patients diagnosed with MTB BSI at Peking Union Medical College Hospital between January 2008 and May 2014 were identified by examining the electronic database listing results of all blood cultures. Data on demographics, clinical characteristics, laboratory manifestations, management, and outcomes were abstracted from medical records. RESULTS: Six thousand nine hundred seventy-four patients had mycobacterial blood cultures during the study period. Of 48 patients (0.7%) with MTB BSI, 26 patients (54%) were considered to be immunocompromised (refers to a person who has a significantly impaired immune system). This was due to human immunodeficiency virus (HIV) infection (n = 2 of 48 tested), receiving steroids (n = 17, including 16 with rheumatic diseases and one with myasthenia gravis), malignancy (n = 3), diabetes mellitus (n = 3), and renal transplantation (n = 1). The main clinical manifestations were fever (100%, with a median of 40 °C), weight loss (48%) and cough with sputum production (46%). Most patients had one or more organs involved (81%). The median time from onset of fever to diagnosis was 8 weeks (IQR 5 ~ 14). Six patients died within 1 week after diagnosis. Of the 17 patients completing treatment, 14 patients (82%) recovered without major complications and they had a shorter time interval between onsets of symptoms to treatment compared to those died of TB. CONCLUSIONS: In this group of patients with MTB BSI, fever and multiple organs involvement were common, the outcome was poor and timely diagnosis and treatment might favor outcome. BioMed Central 2016-12-12 /pmc/articles/PMC5153903/ /pubmed/27955709 http://dx.doi.org/10.1186/s12879-016-2084-z Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Liu, Xiaoqing
Bian, Sainan
Zhang, Yueqiu
Zhang, Lifan
Yang, Qiwen
Wang, Peng
Xu, Yingchun
Shi, Xiaochun
Zhang, Yao
Chemaly, Roy F.
The characteristics of patients with mycobacterium tuberculosis blood stream infections in Beijing, China: a retrospective study
title The characteristics of patients with mycobacterium tuberculosis blood stream infections in Beijing, China: a retrospective study
title_full The characteristics of patients with mycobacterium tuberculosis blood stream infections in Beijing, China: a retrospective study
title_fullStr The characteristics of patients with mycobacterium tuberculosis blood stream infections in Beijing, China: a retrospective study
title_full_unstemmed The characteristics of patients with mycobacterium tuberculosis blood stream infections in Beijing, China: a retrospective study
title_short The characteristics of patients with mycobacterium tuberculosis blood stream infections in Beijing, China: a retrospective study
title_sort characteristics of patients with mycobacterium tuberculosis blood stream infections in beijing, china: a retrospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153903/
https://www.ncbi.nlm.nih.gov/pubmed/27955709
http://dx.doi.org/10.1186/s12879-016-2084-z
work_keys_str_mv AT liuxiaoqing thecharacteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT biansainan thecharacteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT zhangyueqiu thecharacteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT zhanglifan thecharacteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT yangqiwen thecharacteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT wangpeng thecharacteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT xuyingchun thecharacteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT shixiaochun thecharacteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT zhangyao thecharacteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT chemalyroyf thecharacteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT liuxiaoqing characteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT biansainan characteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT zhangyueqiu characteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT zhanglifan characteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT yangqiwen characteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT wangpeng characteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT xuyingchun characteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT shixiaochun characteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT zhangyao characteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy
AT chemalyroyf characteristicsofpatientswithmycobacteriumtuberculosisbloodstreaminfectionsinbeijingchinaaretrospectivestudy