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Association between Body Condition Score and Cancer Prognosis in Dogs with Lymphoma and Osteosarcoma
BACKGROUND: In humans and rodents obesity appears to promote some cancers by increasing incidence, tumor aggressiveness, recurrence, and fatality. However, the relationship between obesity and cancer in dogs has not been thoroughly evaluated. HYPOTHESIS/OBJECTIVES: Whether body condition score (BCS)...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153966/ https://www.ncbi.nlm.nih.gov/pubmed/27279003 http://dx.doi.org/10.1111/jvim.13965 |
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author | Romano, F.R. Heinze, C.R. Barber, L.G. Mason, J.B. Freeman, L.M. |
author_facet | Romano, F.R. Heinze, C.R. Barber, L.G. Mason, J.B. Freeman, L.M. |
author_sort | Romano, F.R. |
collection | PubMed |
description | BACKGROUND: In humans and rodents obesity appears to promote some cancers by increasing incidence, tumor aggressiveness, recurrence, and fatality. However, the relationship between obesity and cancer in dogs has not been thoroughly evaluated. HYPOTHESIS/OBJECTIVES: Whether body condition score (BCS) at the time of lymphoma (LSA) or osteosarcoma (OSA) diagnosis in dogs is predictive of survival time (ST) or progression‐free interval (PFI). We hypothesized that an overweight body state at the time of cancer diagnosis would be associated with negative outcomes. ANIMALS: Dogs with LSA (n = 270) and OSA (n = 54) diagnosed and treated between 2000 and 2010. METHODS: Retrospective case review. Signalment, body weight, BCS, cancer diagnosis and treatment, relevant clinicopathologic values, and survival data were collected. Dogs were grouped by BCS (underweight, ideal, and overweight) and ST and PFI were compared. RESULTS: Overall, 5.5% of dogs were underweight, 54.0% were ideal weight, and 40.4% were overweight at diagnosis. Underweight dogs with LSA had shorter ST (P = .017) than ideal or overweight dogs. BCS was not associated with ST for OSA (P = .474). Progression‐free interval did not differ among BCS categories for either cancer. CONCLUSIONS AND CLINICAL IMPORTANCE: Obesity was not associated with adverse outcomes among dogs with LSA or OSA in this retrospective study; however, being underweight at the time of diagnosis of LSA was associated with shorter survival. More research is needed to elucidate the relationship between excessive body weight and cancer development and progression in dogs. |
format | Online Article Text |
id | pubmed-5153966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51539662016-12-20 Association between Body Condition Score and Cancer Prognosis in Dogs with Lymphoma and Osteosarcoma Romano, F.R. Heinze, C.R. Barber, L.G. Mason, J.B. Freeman, L.M. J Vet Intern Med SMALL ANIMAL BACKGROUND: In humans and rodents obesity appears to promote some cancers by increasing incidence, tumor aggressiveness, recurrence, and fatality. However, the relationship between obesity and cancer in dogs has not been thoroughly evaluated. HYPOTHESIS/OBJECTIVES: Whether body condition score (BCS) at the time of lymphoma (LSA) or osteosarcoma (OSA) diagnosis in dogs is predictive of survival time (ST) or progression‐free interval (PFI). We hypothesized that an overweight body state at the time of cancer diagnosis would be associated with negative outcomes. ANIMALS: Dogs with LSA (n = 270) and OSA (n = 54) diagnosed and treated between 2000 and 2010. METHODS: Retrospective case review. Signalment, body weight, BCS, cancer diagnosis and treatment, relevant clinicopathologic values, and survival data were collected. Dogs were grouped by BCS (underweight, ideal, and overweight) and ST and PFI were compared. RESULTS: Overall, 5.5% of dogs were underweight, 54.0% were ideal weight, and 40.4% were overweight at diagnosis. Underweight dogs with LSA had shorter ST (P = .017) than ideal or overweight dogs. BCS was not associated with ST for OSA (P = .474). Progression‐free interval did not differ among BCS categories for either cancer. CONCLUSIONS AND CLINICAL IMPORTANCE: Obesity was not associated with adverse outcomes among dogs with LSA or OSA in this retrospective study; however, being underweight at the time of diagnosis of LSA was associated with shorter survival. More research is needed to elucidate the relationship between excessive body weight and cancer development and progression in dogs. John Wiley and Sons Inc. 2016-06-08 2016 /pmc/articles/PMC5153966/ /pubmed/27279003 http://dx.doi.org/10.1111/jvim.13965 Text en Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | SMALL ANIMAL Romano, F.R. Heinze, C.R. Barber, L.G. Mason, J.B. Freeman, L.M. Association between Body Condition Score and Cancer Prognosis in Dogs with Lymphoma and Osteosarcoma |
title | Association between Body Condition Score and Cancer Prognosis in Dogs with Lymphoma and Osteosarcoma |
title_full | Association between Body Condition Score and Cancer Prognosis in Dogs with Lymphoma and Osteosarcoma |
title_fullStr | Association between Body Condition Score and Cancer Prognosis in Dogs with Lymphoma and Osteosarcoma |
title_full_unstemmed | Association between Body Condition Score and Cancer Prognosis in Dogs with Lymphoma and Osteosarcoma |
title_short | Association between Body Condition Score and Cancer Prognosis in Dogs with Lymphoma and Osteosarcoma |
title_sort | association between body condition score and cancer prognosis in dogs with lymphoma and osteosarcoma |
topic | SMALL ANIMAL |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153966/ https://www.ncbi.nlm.nih.gov/pubmed/27279003 http://dx.doi.org/10.1111/jvim.13965 |
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