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Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis

BACKGROUND: Myocardial fibrosis is being increasingly recognised as a common final pathway of a wide range of diseases. Thus, the development of an accurate and convenient method to evaluate myocardial fibrosis is of major importance. Although T1 mapping is a potential alternative for myocardial bio...

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Autores principales: Diao, Kai-yue, Yang, Zhi-gang, Xu, Hua-yan, Liu, Xi, Zhang, Qin, Shi, Ke, Jiang, Li, Xie, Lin-jun, Wen, Ling-yi, Guo, Ying-kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154013/
https://www.ncbi.nlm.nih.gov/pubmed/27955698
http://dx.doi.org/10.1186/s12968-016-0313-7
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author Diao, Kai-yue
Yang, Zhi-gang
Xu, Hua-yan
Liu, Xi
Zhang, Qin
Shi, Ke
Jiang, Li
Xie, Lin-jun
Wen, Ling-yi
Guo, Ying-kun
author_facet Diao, Kai-yue
Yang, Zhi-gang
Xu, Hua-yan
Liu, Xi
Zhang, Qin
Shi, Ke
Jiang, Li
Xie, Lin-jun
Wen, Ling-yi
Guo, Ying-kun
author_sort Diao, Kai-yue
collection PubMed
description BACKGROUND: Myocardial fibrosis is being increasingly recognised as a common final pathway of a wide range of diseases. Thus, the development of an accurate and convenient method to evaluate myocardial fibrosis is of major importance. Although T1 mapping is a potential alternative for myocardial biopsy, validation studies are limited to small numbers and vary regarding technical facets, and include only a restricted number of disease. A systematic review and meta-analysis was conducted to objectively and comprehensively evaluate the performance of T1 mapping on the quantification of myocardial fibrosis using cardiovascular magnetic resonance (CMR). METHODS: PubMed, EMBASE and the Cochrane Library databases were searched for studies applying T1 mapping to measure myocardial fibrosis and that validated the results via histological analysis. A pooled correlation coefficient between the CMR and histology measurements was used to evaluate the performance of the T1 mapping. RESULTS: A total of 15 studies, including 308 patients who had CMR and myocardial biopsy were included and the pooled correlation coefficient between ECV measured by T1 mapping and biopsy for the selected studies was 0.884 (95% CI: 0.854, 0.914) and was not notably heterogeneous chi-squared = 7.44; P = 0.489 for the Q test and I^2 = 0.00%). CONCLUSIONS: The quantitative measurement of myocardial fibrosis via T1 mapping is associated with a favourable overall correlation with the myocardial biopsy measurements. Further studies are required to determine the calibration of the T1 mapping results for the biopsy findings of different cardiomyopathies.
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spelling pubmed-51540132016-12-20 Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis Diao, Kai-yue Yang, Zhi-gang Xu, Hua-yan Liu, Xi Zhang, Qin Shi, Ke Jiang, Li Xie, Lin-jun Wen, Ling-yi Guo, Ying-kun J Cardiovasc Magn Reson Research BACKGROUND: Myocardial fibrosis is being increasingly recognised as a common final pathway of a wide range of diseases. Thus, the development of an accurate and convenient method to evaluate myocardial fibrosis is of major importance. Although T1 mapping is a potential alternative for myocardial biopsy, validation studies are limited to small numbers and vary regarding technical facets, and include only a restricted number of disease. A systematic review and meta-analysis was conducted to objectively and comprehensively evaluate the performance of T1 mapping on the quantification of myocardial fibrosis using cardiovascular magnetic resonance (CMR). METHODS: PubMed, EMBASE and the Cochrane Library databases were searched for studies applying T1 mapping to measure myocardial fibrosis and that validated the results via histological analysis. A pooled correlation coefficient between the CMR and histology measurements was used to evaluate the performance of the T1 mapping. RESULTS: A total of 15 studies, including 308 patients who had CMR and myocardial biopsy were included and the pooled correlation coefficient between ECV measured by T1 mapping and biopsy for the selected studies was 0.884 (95% CI: 0.854, 0.914) and was not notably heterogeneous chi-squared = 7.44; P = 0.489 for the Q test and I^2 = 0.00%). CONCLUSIONS: The quantitative measurement of myocardial fibrosis via T1 mapping is associated with a favourable overall correlation with the myocardial biopsy measurements. Further studies are required to determine the calibration of the T1 mapping results for the biopsy findings of different cardiomyopathies. BioMed Central 2016-12-12 /pmc/articles/PMC5154013/ /pubmed/27955698 http://dx.doi.org/10.1186/s12968-016-0313-7 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Diao, Kai-yue
Yang, Zhi-gang
Xu, Hua-yan
Liu, Xi
Zhang, Qin
Shi, Ke
Jiang, Li
Xie, Lin-jun
Wen, Ling-yi
Guo, Ying-kun
Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis
title Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis
title_full Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis
title_fullStr Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis
title_full_unstemmed Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis
title_short Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis
title_sort histologic validation of myocardial fibrosis measured by t1 mapping: a systematic review and meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154013/
https://www.ncbi.nlm.nih.gov/pubmed/27955698
http://dx.doi.org/10.1186/s12968-016-0313-7
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