Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery

BACKGROUND: The relationship between monogenic and polygenic forms of epilepsy is poorly understood and the extent to which the genetic and acquired epilepsies share common pathways is unclear. Here, we use an integrated systems-level analysis of brain gene expression data to identify molecular netw...

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Detalles Bibliográficos
Autores principales: Delahaye-Duriez, Andree, Srivastava, Prashant, Shkura, Kirill, Langley, Sarah R., Laaniste, Liisi, Moreno-Moral, Aida, Danis, Bénédicte, Mazzuferi, Manuela, Foerch, Patrik, Gazina, Elena V., Richards, Kay, Petrou, Steven, Kaminski, Rafal M., Petretto, Enrico, Johnson, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154105/
https://www.ncbi.nlm.nih.gov/pubmed/27955713
http://dx.doi.org/10.1186/s13059-016-1097-7

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