Viral Vector-Based Targeting of miR-21 in Cardiac Nonmyocyte Cells Reduces Pathologic Remodeling of the Heart

Systemic inhibition of miR-21 has proven effective against myocardial fibrosis and dysfunction, while studies in cardiac myocytes suggested a protective role in this cell type. Considering potential implications for therapy, we aimed to determine the cell fraction where miR-21 exerts its pathologica...

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Detalles Bibliográficos
Autores principales: Ramanujam, Deepak, Sassi, Yassine, Laggerbauer, Bernhard, Engelhardt, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154480/
https://www.ncbi.nlm.nih.gov/pubmed/27545313
http://dx.doi.org/10.1038/mt.2016.166

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