MATE2 Expression Is Associated with Cancer Cell Response to Metformin

BACKGROUND: There is great interest in repurposing the commonly prescribed anti-diabetic drug metformin for cancer therapy. Intracellular uptake and retention of metformin is affected by the expression of organic cation transporters (OCT) 1–3 and by multidrug and toxic compound extrusion (MATE) 1–2....

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Detalles Bibliográficos
Autores principales: Chowdhury, Sanjana, Yung, Eric, Pintilie, Melania, Muaddi, Hala, Chaib, Selim, Yeung, ManTek, Fusciello, Manlio, Sykes, Jenna, Pitcher, Bethany, Hagenkort, Anna, McKee, Trevor, Vellanki, Ravi, Chen, Eric, Bristow, Robert G., Wouters, Bradly G., Koritzinsky, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154501/
https://www.ncbi.nlm.nih.gov/pubmed/27959931
http://dx.doi.org/10.1371/journal.pone.0165214

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