Stabilization of Human Serum Albumin by the Binding of Phycocyanobilin, a Bioactive Chromophore of Blue-Green Alga Spirulina: Molecular Dynamics and Experimental Study

Phycocyanobilin (PCB) binds with high affinity (2.2 x 10(6) M(-1) at 25°C) to human serum albumin (HSA) at sites located in IB and IIA subdomains. The aim of this study was to examine effects of PCB binding on protein conformation and stability. Using 300 ns molecular dynamics (MD) simulations, UV-V...

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Detalles Bibliográficos
Autores principales: Radibratovic, Milica, Minic, Simeon, Stanic-Vucinic, Dragana, Nikolic, Milan, Milcic, Milos, Cirkovic Velickovic, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154526/
https://www.ncbi.nlm.nih.gov/pubmed/27959940
http://dx.doi.org/10.1371/journal.pone.0167973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154526/
https://www.ncbi.nlm.nih.gov/pubmed/27959940
http://dx.doi.org/10.1371/journal.pone.0167973

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