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Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage

Isolates of the human pathogen Mycobacterium tuberculosis recovered from clinical samples exhibit genetic heterogeneity. Such variation may result from the stressful environment encountered by the pathogen inside the macrophage, which is the host cell tubercle bacilli parasitize. To study the evolut...

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Detalles Bibliográficos
Autores principales:	Guerrini, Valentina, Subbian, Selvakumar, Santucci, Pierre, Canaan, Stéphane, Gennaro, Maria Laura, Pozzi, Gianni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154527/ https://www.ncbi.nlm.nih.gov/pubmed/27959952 http://dx.doi.org/10.1371/journal.pone.0167989

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