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The Effects of Ca(2+) Concentration and E200K Mutation on the Aggregation Propensity of PrP(C): A Computational Study
The propensity of cellular prion protein to aggregation is reputed essential for the initiation of the amyloid cascade that ultimately lead to the accumulation of neurotoxic aggregates. In this paper, we extended and applied an already reported computational workflow [Proteins 2015; 83: 1751–1765] t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154561/ https://www.ncbi.nlm.nih.gov/pubmed/27959938 http://dx.doi.org/10.1371/journal.pone.0168039 |