Cargando…

Electrocardiographic changes in patients with tramadol-induced idiosyncratic seizures

OBJECTIVES: To assess ECG changes in patients with tramadol-induced seizure(s) and compare these changes in lower and higher than 500 mg tramadol doses as a main goal. MATERIAL AND METHODS: In an analytical-cross sectional manner over 1 year, 170 patients with idiosyncratic seizure(s) after using tr...

Descripción completa

Detalles Bibliográficos
Autores principales: Hafezi Moghadam, Peyman, Zarei, Najmeh, Farsi, Davood, Abbasi, Saeed, Mofidi, Mani, Rezai, Mahdi, Mahshidfar, Babak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154583/
https://www.ncbi.nlm.nih.gov/pubmed/27995207
http://dx.doi.org/10.1016/j.tjem.2016.08.005
_version_ 1782474893818855424
author Hafezi Moghadam, Peyman
Zarei, Najmeh
Farsi, Davood
Abbasi, Saeed
Mofidi, Mani
Rezai, Mahdi
Mahshidfar, Babak
author_facet Hafezi Moghadam, Peyman
Zarei, Najmeh
Farsi, Davood
Abbasi, Saeed
Mofidi, Mani
Rezai, Mahdi
Mahshidfar, Babak
author_sort Hafezi Moghadam, Peyman
collection PubMed
description OBJECTIVES: To assess ECG changes in patients with tramadol-induced seizure(s) and compare these changes in lower and higher than 500 mg tramadol doses as a main goal. MATERIAL AND METHODS: In an analytical-cross sectional manner over 1 year, 170 patients with idiosyncratic seizure(s) after using tramadol, were studied. Full data were recorded for each patient. ECGs were taken from all the patients on admission and 1 h later and were assessed for findings. RESULTS: 70 of 170 patients (41.2%) had used lower than 500 mg doses of tramadol while 90 patients (52.9%) were included in the high dose group. Rate of female patients in the high dose group was significantly higher. The average age of patients in the high dose group was significantly lower (22.04 vs 25.76). The high dose group had significantly higher heart rates. There was no history of cardiovascular diseases; two patients had previous history of seizure. No significant difference was shown between low dose and high dose groups from the point of ECG changes. DISCUSSION AND CONCLUSION: Using doses higher than 500 mg is more frequently seen in women, young people and those who have not experienced previous use of tramadol. Terminal S wave, sinus tachycardia, and terminal R wave in the lead aVR are among the most common ECG changes in tramadol users.
format Online
Article
Text
id pubmed-5154583
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-51545832016-12-19 Electrocardiographic changes in patients with tramadol-induced idiosyncratic seizures Hafezi Moghadam, Peyman Zarei, Najmeh Farsi, Davood Abbasi, Saeed Mofidi, Mani Rezai, Mahdi Mahshidfar, Babak Turk J Emerg Med Original Article OBJECTIVES: To assess ECG changes in patients with tramadol-induced seizure(s) and compare these changes in lower and higher than 500 mg tramadol doses as a main goal. MATERIAL AND METHODS: In an analytical-cross sectional manner over 1 year, 170 patients with idiosyncratic seizure(s) after using tramadol, were studied. Full data were recorded for each patient. ECGs were taken from all the patients on admission and 1 h later and were assessed for findings. RESULTS: 70 of 170 patients (41.2%) had used lower than 500 mg doses of tramadol while 90 patients (52.9%) were included in the high dose group. Rate of female patients in the high dose group was significantly higher. The average age of patients in the high dose group was significantly lower (22.04 vs 25.76). The high dose group had significantly higher heart rates. There was no history of cardiovascular diseases; two patients had previous history of seizure. No significant difference was shown between low dose and high dose groups from the point of ECG changes. DISCUSSION AND CONCLUSION: Using doses higher than 500 mg is more frequently seen in women, young people and those who have not experienced previous use of tramadol. Terminal S wave, sinus tachycardia, and terminal R wave in the lead aVR are among the most common ECG changes in tramadol users. Elsevier 2016-09-16 /pmc/articles/PMC5154583/ /pubmed/27995207 http://dx.doi.org/10.1016/j.tjem.2016.08.005 Text en Copyright © 2016 The Emergency Medicine Association of Turkey. Production and hosting by Elsevier B.V. on behalf of the Owner. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Hafezi Moghadam, Peyman
Zarei, Najmeh
Farsi, Davood
Abbasi, Saeed
Mofidi, Mani
Rezai, Mahdi
Mahshidfar, Babak
Electrocardiographic changes in patients with tramadol-induced idiosyncratic seizures
title Electrocardiographic changes in patients with tramadol-induced idiosyncratic seizures
title_full Electrocardiographic changes in patients with tramadol-induced idiosyncratic seizures
title_fullStr Electrocardiographic changes in patients with tramadol-induced idiosyncratic seizures
title_full_unstemmed Electrocardiographic changes in patients with tramadol-induced idiosyncratic seizures
title_short Electrocardiographic changes in patients with tramadol-induced idiosyncratic seizures
title_sort electrocardiographic changes in patients with tramadol-induced idiosyncratic seizures
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154583/
https://www.ncbi.nlm.nih.gov/pubmed/27995207
http://dx.doi.org/10.1016/j.tjem.2016.08.005
work_keys_str_mv AT hafezimoghadampeyman electrocardiographicchangesinpatientswithtramadolinducedidiosyncraticseizures
AT zareinajmeh electrocardiographicchangesinpatientswithtramadolinducedidiosyncraticseizures
AT farsidavood electrocardiographicchangesinpatientswithtramadolinducedidiosyncraticseizures
AT abbasisaeed electrocardiographicchangesinpatientswithtramadolinducedidiosyncraticseizures
AT mofidimani electrocardiographicchangesinpatientswithtramadolinducedidiosyncraticseizures
AT rezaimahdi electrocardiographicchangesinpatientswithtramadolinducedidiosyncraticseizures
AT mahshidfarbabak electrocardiographicchangesinpatientswithtramadolinducedidiosyncraticseizures