Pathogenesis of Fungal Infections in Cystic Fibrosis

For a long time, the microbiology of cystic fibrosis has been focussed on Pseudomonas aeruginosa and associated Gram-negative pathogens. An increasing body of evidence has been compiled demonstrating an important role for moulds and yeasts within this complex patient group. Whether or not fungi are...

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Detalles Bibliográficos
Autores principales: Williams, Craig, Ranjendran, Ranjith, Ramage, Gordon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Fungal Genomics and Pathogenesis (S Shoham, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155017/
https://www.ncbi.nlm.nih.gov/pubmed/28035247
http://dx.doi.org/10.1007/s12281-016-0268-z
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author Williams, Craig
Ranjendran, Ranjith
Ramage, Gordon
author_facet Williams, Craig
Ranjendran, Ranjith
Ramage, Gordon
author_sort Williams, Craig
collection PubMed
description For a long time, the microbiology of cystic fibrosis has been focussed on Pseudomonas aeruginosa and associated Gram-negative pathogens. An increasing body of evidence has been compiled demonstrating an important role for moulds and yeasts within this complex patient group. Whether or not fungi are active participants, spectators or transient passersby remain to be elucidated. However, functionally, they do appear to play a contributory role in pathogenesis, albeit we do not know if this is a direct or indirect effect. The following review examines some of the key evidence for the role of fungi in CF pathogenesis.
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spelling pubmed-51550172016-12-27 Pathogenesis of Fungal Infections in Cystic Fibrosis Williams, Craig Ranjendran, Ranjith Ramage, Gordon Curr Fungal Infect Rep Fungal Genomics and Pathogenesis (S Shoham, Section Editor) For a long time, the microbiology of cystic fibrosis has been focussed on Pseudomonas aeruginosa and associated Gram-negative pathogens. An increasing body of evidence has been compiled demonstrating an important role for moulds and yeasts within this complex patient group. Whether or not fungi are active participants, spectators or transient passersby remain to be elucidated. However, functionally, they do appear to play a contributory role in pathogenesis, albeit we do not know if this is a direct or indirect effect. The following review examines some of the key evidence for the role of fungi in CF pathogenesis. Springer US 2016-12-07 2016 /pmc/articles/PMC5155017/ /pubmed/28035247 http://dx.doi.org/10.1007/s12281-016-0268-z Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Fungal Genomics and Pathogenesis (S Shoham, Section Editor)
Williams, Craig
Ranjendran, Ranjith
Ramage, Gordon
Pathogenesis of Fungal Infections in Cystic Fibrosis
title Pathogenesis of Fungal Infections in Cystic Fibrosis
title_full Pathogenesis of Fungal Infections in Cystic Fibrosis
title_fullStr Pathogenesis of Fungal Infections in Cystic Fibrosis
title_full_unstemmed Pathogenesis of Fungal Infections in Cystic Fibrosis
title_short Pathogenesis of Fungal Infections in Cystic Fibrosis
title_sort pathogenesis of fungal infections in cystic fibrosis
topic Fungal Genomics and Pathogenesis (S Shoham, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155017/
https://www.ncbi.nlm.nih.gov/pubmed/28035247
http://dx.doi.org/10.1007/s12281-016-0268-z
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