Eye on the B-ALL: B-cell receptor repertoires reveal persistence of numerous B-lymphoblastic leukemia subclones from diagnosis to relapse

The strongest predictor of relapse in B-cell acute lymphoblastic leukemia (B-ALL) is the level of persistence of tumor cells after initial therapy. The high mutation rate of the B-cell receptor (BCR) locus allows high-resolution tracking of the architecture, evolution and clonal dynamics of B-ALL. U...

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Detalles Bibliográficos
Autores principales: Bashford-Rogers, R J M, Nicolaou, K A, Bartram, J, Goulden, N J, Loizou, L, Koumas, L, Chi, J, Hubank, M, Kellam, P, Costeas, P A, Vassiliou, G S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155029/
https://www.ncbi.nlm.nih.gov/pubmed/27211266
http://dx.doi.org/10.1038/leu.2016.142

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