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A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice

Sirt1, AMPK, and eNOS modulate hepatic energy metabolism and inflammation and are key players in the development of NASH. L-leucine, an allosteric Sirt1 activator, synergizes with low doses of metformin or sildenafil on the AMPK-eNOS-Sirt1 pathway to reverse mild NAFLD in preclinical mouse models. H...

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Detalles Bibliográficos
Autores principales:	Bruckbauer, Antje, Banerjee, Jheelam, Fu, Lizhi, Li, Fenfen, Cao, Qiang, Cui, Xin, Wu, Rui, Shi, Hang, Xue, Bingzhong, Zemel, Michael B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155097/ https://www.ncbi.nlm.nih.gov/pubmed/28042486 http://dx.doi.org/10.1155/2016/9185987

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