PTEN Activation by DNA Damage Induces Protective Autophagy in Response to Cucurbitacin B in Hepatocellular Carcinoma Cells

Cucurbitacin B (Cuc B), a natural product, induced both protective autophagy and DNA damage mediated by ROS while the detailed mechanisms remain unclear. This study explored the mechanism of Cuc B-induced DNA damage and autophagy. Cuc B decreased cell viability in concentration- and time-dependent m...

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Detalles Bibliográficos
Autores principales: Niu, Yanan, Sun, Wen, Lu, Jin-Jian, Ma, Dik-Lung, Leung, Chung-Hang, Pei, Lixia, Chen, Xiuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155108/
https://www.ncbi.nlm.nih.gov/pubmed/28042385
http://dx.doi.org/10.1155/2016/4313204

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