The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

The NLRP3 inflammasome has a fundamental role in host defence against microbial pathogens and its deregulation may cause diverse inflammatory diseases. NLRP3 protein expression is a rate-limiting step for inflammasome activation, thus its expression must be tightly controlled to maintain immune home...

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Detalles Bibliográficos
Autores principales: Song, Hui, Liu, Bingyu, Huai, Wanwan, Yu, Zhongxia, Wang, Wenwen, Zhao, Jing, Han, Lihui, Jiang, Guosheng, Zhang, Lining, Gao, Chengjiang, Zhao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155141/
https://www.ncbi.nlm.nih.gov/pubmed/27929086
http://dx.doi.org/10.1038/ncomms13727

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