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Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus

The release of GABA from local interneurons in the dorsal lateral geniculate nucleus (dLGN-INs) provides inhibitory control during visual processing within the thalamus. It is commonly assumed that this important class of interneurons originates from within the thalamic complex, but we now show that...

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Autores principales: Jager, Polona, Ye, Zhiwen, Yu, Xiao, Zagoraiou, Laskaro, Prekop, Hong-Ting, Partanen, Juha, Jessell, Thomas M., Wisden, William, Brickley, Stephen G., Delogu, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155147/
https://www.ncbi.nlm.nih.gov/pubmed/27929058
http://dx.doi.org/10.1038/ncomms13579
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author Jager, Polona
Ye, Zhiwen
Yu, Xiao
Zagoraiou, Laskaro
Prekop, Hong-Ting
Partanen, Juha
Jessell, Thomas M.
Wisden, William
Brickley, Stephen G.
Delogu, Alessio
author_facet Jager, Polona
Ye, Zhiwen
Yu, Xiao
Zagoraiou, Laskaro
Prekop, Hong-Ting
Partanen, Juha
Jessell, Thomas M.
Wisden, William
Brickley, Stephen G.
Delogu, Alessio
author_sort Jager, Polona
collection PubMed
description The release of GABA from local interneurons in the dorsal lateral geniculate nucleus (dLGN-INs) provides inhibitory control during visual processing within the thalamus. It is commonly assumed that this important class of interneurons originates from within the thalamic complex, but we now show that during early postnatal development Sox14/Otx2-expressing precursor cells migrate from the dorsal midbrain to generate dLGN-INs. The unexpected extra-diencephalic origin of dLGN-INs sets them apart from GABAergic neurons of the reticular thalamic nucleus. Using optogenetics we show that at increased firing rates tectal-derived dLGN-INs generate a powerful form of tonic inhibition that regulates the gain of thalamic relay neurons through recruitment of extrasynaptic high-affinity GABA(A) receptors. Therefore, by revising the conventional view of thalamic interneuron ontogeny we demonstrate how a previously unappreciated mesencephalic population controls thalamic relay neuron excitability.
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spelling pubmed-51551472016-12-21 Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus Jager, Polona Ye, Zhiwen Yu, Xiao Zagoraiou, Laskaro Prekop, Hong-Ting Partanen, Juha Jessell, Thomas M. Wisden, William Brickley, Stephen G. Delogu, Alessio Nat Commun Article The release of GABA from local interneurons in the dorsal lateral geniculate nucleus (dLGN-INs) provides inhibitory control during visual processing within the thalamus. It is commonly assumed that this important class of interneurons originates from within the thalamic complex, but we now show that during early postnatal development Sox14/Otx2-expressing precursor cells migrate from the dorsal midbrain to generate dLGN-INs. The unexpected extra-diencephalic origin of dLGN-INs sets them apart from GABAergic neurons of the reticular thalamic nucleus. Using optogenetics we show that at increased firing rates tectal-derived dLGN-INs generate a powerful form of tonic inhibition that regulates the gain of thalamic relay neurons through recruitment of extrasynaptic high-affinity GABA(A) receptors. Therefore, by revising the conventional view of thalamic interneuron ontogeny we demonstrate how a previously unappreciated mesencephalic population controls thalamic relay neuron excitability. Nature Publishing Group 2016-12-08 /pmc/articles/PMC5155147/ /pubmed/27929058 http://dx.doi.org/10.1038/ncomms13579 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Jager, Polona
Ye, Zhiwen
Yu, Xiao
Zagoraiou, Laskaro
Prekop, Hong-Ting
Partanen, Juha
Jessell, Thomas M.
Wisden, William
Brickley, Stephen G.
Delogu, Alessio
Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus
title Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus
title_full Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus
title_fullStr Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus
title_full_unstemmed Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus
title_short Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus
title_sort tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155147/
https://www.ncbi.nlm.nih.gov/pubmed/27929058
http://dx.doi.org/10.1038/ncomms13579
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