K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression

Intratumoural hypoxia induces HIF-1α and promotes tumour progression, metastasis and treatment resistance. HIF-1α stability is regulated by VHL-E3 ligase-mediated ubiquitin-dependent degradation; however, the hypoxia-regulated deubiquitinase that stabilizes HIF-1α has not been identified. Here we re...

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Detalles Bibliográficos
Autores principales: Wu, Han-Tsang, Kuo, Yi-Chih, Hung, Jung-Jyh, Huang, Chi-Hung, Chen, Wei-Yi, Chou, Teh-Ying, Chen, Yeh, Chen, Yi-Ju, Chen, Yu-Ju, Cheng, Wei-Chung, Teng, Shu-Chun, Wu, Kou-Juey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155157/
https://www.ncbi.nlm.nih.gov/pubmed/27934968
http://dx.doi.org/10.1038/ncomms13644

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