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Correlation between colonic secretion and colonic motility in rats: Role of ghrelin

AIM: To explore the relationship between colonic secretory function and colonic motility. METHODS: Using a rat model chronically implanted with intracerebroventricular (ICV) and cecal catheters, we validated the correlation between colonic secretion and colonic motor functions, as well as the role o...

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Autores principales: Huang, Hsien-Hao, Ting, Ching-Heng, Syu, Yu-Fong, Chang, Shi-Chuan, Chen, Chih-Yen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155173/
https://www.ncbi.nlm.nih.gov/pubmed/28028362
http://dx.doi.org/10.3748/wjg.v22.i46.10140
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author Huang, Hsien-Hao
Ting, Ching-Heng
Syu, Yu-Fong
Chang, Shi-Chuan
Chen, Chih-Yen
author_facet Huang, Hsien-Hao
Ting, Ching-Heng
Syu, Yu-Fong
Chang, Shi-Chuan
Chen, Chih-Yen
author_sort Huang, Hsien-Hao
collection PubMed
description AIM: To explore the relationship between colonic secretory function and colonic motility. METHODS: Using a rat model chronically implanted with intracerebroventricular (ICV) and cecal catheters, we validated the correlation between colonic secretion and colonic motor functions, as well as the role of ICV injection volume. RESULTS: Compared to saline controls (5 μL/rat), ICV acyl ghrelin at 1 nmol/5 μL enhanced the total fecal weight, accelerated the colonic transit time, and increased the fecal pellet output during the first hour post-injection, while ICV des-acyl ghrelin at 1 nmol/5 μL only accelerated the colonic transit time. These stimulatory effects on colonic motility and/or secretion from acyl ghrelin and des-acyl ghrelin disappeared when the ICV injection volume increased to 10 μL compared with saline controls (10 μL/rat). Additionally, the ICV injection of 10 μL of saline significantly shortened the colonic transit time compared with the ICV injection of 5 μL of saline. The total fecal weight during the first hour post-injection correlated with the colonic transit time and fecal pellet output after the ICV injection of acyl ghrelin (1 nmol/5 μL), whereas the total fecal weight during the first hour post-injection correlated with the fecal pellet output but not the colonic transit time after the ICV injection of des-acyl ghrelin (1 nmol/5 μL). CONCLUSION: Colonic secretion does not always correlate with colonic motility in response to different colonic stimulations. Acyl ghrelin stimulates colonic secretion.
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spelling pubmed-51551732016-12-27 Correlation between colonic secretion and colonic motility in rats: Role of ghrelin Huang, Hsien-Hao Ting, Ching-Heng Syu, Yu-Fong Chang, Shi-Chuan Chen, Chih-Yen World J Gastroenterol Basic Study AIM: To explore the relationship between colonic secretory function and colonic motility. METHODS: Using a rat model chronically implanted with intracerebroventricular (ICV) and cecal catheters, we validated the correlation between colonic secretion and colonic motor functions, as well as the role of ICV injection volume. RESULTS: Compared to saline controls (5 μL/rat), ICV acyl ghrelin at 1 nmol/5 μL enhanced the total fecal weight, accelerated the colonic transit time, and increased the fecal pellet output during the first hour post-injection, while ICV des-acyl ghrelin at 1 nmol/5 μL only accelerated the colonic transit time. These stimulatory effects on colonic motility and/or secretion from acyl ghrelin and des-acyl ghrelin disappeared when the ICV injection volume increased to 10 μL compared with saline controls (10 μL/rat). Additionally, the ICV injection of 10 μL of saline significantly shortened the colonic transit time compared with the ICV injection of 5 μL of saline. The total fecal weight during the first hour post-injection correlated with the colonic transit time and fecal pellet output after the ICV injection of acyl ghrelin (1 nmol/5 μL), whereas the total fecal weight during the first hour post-injection correlated with the fecal pellet output but not the colonic transit time after the ICV injection of des-acyl ghrelin (1 nmol/5 μL). CONCLUSION: Colonic secretion does not always correlate with colonic motility in response to different colonic stimulations. Acyl ghrelin stimulates colonic secretion. Baishideng Publishing Group Inc 2016-12-14 2016-12-14 /pmc/articles/PMC5155173/ /pubmed/28028362 http://dx.doi.org/10.3748/wjg.v22.i46.10140 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Basic Study
Huang, Hsien-Hao
Ting, Ching-Heng
Syu, Yu-Fong
Chang, Shi-Chuan
Chen, Chih-Yen
Correlation between colonic secretion and colonic motility in rats: Role of ghrelin
title Correlation between colonic secretion and colonic motility in rats: Role of ghrelin
title_full Correlation between colonic secretion and colonic motility in rats: Role of ghrelin
title_fullStr Correlation between colonic secretion and colonic motility in rats: Role of ghrelin
title_full_unstemmed Correlation between colonic secretion and colonic motility in rats: Role of ghrelin
title_short Correlation between colonic secretion and colonic motility in rats: Role of ghrelin
title_sort correlation between colonic secretion and colonic motility in rats: role of ghrelin
topic Basic Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155173/
https://www.ncbi.nlm.nih.gov/pubmed/28028362
http://dx.doi.org/10.3748/wjg.v22.i46.10140
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