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Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia

Familial hypercholesterolemia (FH) is a life-threatening genetic disorder characterized by elevated levels of plasma low-density lipoprotein cholesterol (LDL-cholesterol). Current attempts at gene therapy for FH have been limited by the use of strong heterologous promoters which lack genomic DNA ele...

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Detalles Bibliográficos
Autores principales:	Kerr, Alastair G, Tam, Lawrence CS, Hale, Ashley B, Cioroch, Milena, Douglas, Gillian, Channon, Keith M, Wade-Martins, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155321/ https://www.ncbi.nlm.nih.gov/pubmed/27824334 http://dx.doi.org/10.1038/mtna.2016.86

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