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In vivo Editing of the Human Mutant Rhodopsin Gene by Electroporation of Plasmid-based CRISPR/Cas9 in the Mouse Retina

The bacterial CRISPR/Cas system has proven to be an efficient tool for genetic manipulation in various organisms. Here we show the application of CRISPR-Cas9 technology to edit the human Rhodopsin (RHO) gene in a mouse model for autosomal dominant Retinitis Pigmentosa. We designed single or double s...

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Detalles Bibliográficos
Autores principales:	Latella, Maria Carmela, Di Salvo, Maria Teresa, Cocchiarella, Fabienne, Benati, Daniela, Grisendi, Giulia, Comitato, Antonella, Marigo, Valeria, Recchia, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155324/ https://www.ncbi.nlm.nih.gov/pubmed/27874856 http://dx.doi.org/10.1038/mtna.2016.92

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