Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

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BACKGROUND: Although the nuclear factor-erythroid 2-related factor 2 (NRF2) pathway is one of the most frequently dysregulated in cancer, it is not clear whether mutational status is a good predictor of NRF2 activity. Here we utilise four members of the aldo-keto reductase (AKR) superfamily as bioma...

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Detalles Bibliográficos
Autores principales: MacLeod, A Kenneth, Acosta-Jimenez, Lourdes, Coates, Philip J, McMahon, Michael, Carey, Frank A, Honda, Tadashi, Henderson, Colin J, Wolf, C Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155360/
https://www.ncbi.nlm.nih.gov/pubmed/27824809
http://dx.doi.org/10.1038/bjc.2016.363
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