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Fatal asthma; is it still an epidemic?
BACKGROUND: Asthma mortality has declined since the 1980s. Nevertheless the World Health Organization (WHO) identified asthma as responsible for 225.000 deaths worldwide in 2005, and 430.000 fatal cases are expected by 2030. Some unexpected and concentrated fatal asthma events all occurred between 2...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155395/ https://www.ncbi.nlm.nih.gov/pubmed/28031774 http://dx.doi.org/10.1186/s40413-016-0129-9 |
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author | Vianello, Andrea Caminati, Marco Crivellaro, Mariangiola El Mazloum, Rafi Snenghi, Rossella Schiappoli, Michele Dama, Annarita Rossi, Andrea Festi, Giuliana Marchi, Maria Rita Bovo, Chiara Canonica, Giorgio Walter Senna, Gianenrico |
author_facet | Vianello, Andrea Caminati, Marco Crivellaro, Mariangiola El Mazloum, Rafi Snenghi, Rossella Schiappoli, Michele Dama, Annarita Rossi, Andrea Festi, Giuliana Marchi, Maria Rita Bovo, Chiara Canonica, Giorgio Walter Senna, Gianenrico |
author_sort | Vianello, Andrea |
collection | PubMed |
description | BACKGROUND: Asthma mortality has declined since the 1980s. Nevertheless the World Health Organization (WHO) identified asthma as responsible for 225.000 deaths worldwide in 2005, and 430.000 fatal cases are expected by 2030. Some unexpected and concentrated fatal asthma events all occurred between 2013 and 2015 in Veneto, a North Eastern region of Italy, which prompted a more in-depth investigation of characteristics and risk factors. METHODS: A web search including key words related to fatal asthma in Italy between 2013 and 2015 has been performed. Concerning the cases that occurred in Veneto, subjects’ clinical records have been evaluated and details about concomitant weather conditions, pollutants and pollen count have been collected. RESULTS: Twenty-three cases of asthma deaths were found in Italy; 16 of them (69%) occurred in the Veneto Region. A prevalence of male and young age was observed. Most of patients were atopic, died in the night-time hours and during the weekends. The possible risk factors identified were the sensitization to alternaria, previous near fatal asthma attacks and the incorrect treatment of the disease. Weather condition did not appear to be related to the fatal exacerbations, whereas among the pollutants only ozone was detected over the accepted limits. Smoking habits, possible drug abuse and concomitant complementary therapies might be regarded as further risk factors. DISCUSSION: Although not free from potential biases, our web search and further investigations highlight an increasing asthma mortality trend, similarly to what other observatories report. The analysis of available clinical data suggests that the lack of treatment more than a severe asthma phenotype characterizes the fatal events. CONCLUSIONS: Asthma mortality still represents a critical issue in the management of the disease, particularly in youngsters. Once more the inadequate treatment and the lack of adherence seem to be not only related to the uncontrolled asthma but also to asthma mortality. |
format | Online Article Text |
id | pubmed-5155395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-51553952016-12-28 Fatal asthma; is it still an epidemic? Vianello, Andrea Caminati, Marco Crivellaro, Mariangiola El Mazloum, Rafi Snenghi, Rossella Schiappoli, Michele Dama, Annarita Rossi, Andrea Festi, Giuliana Marchi, Maria Rita Bovo, Chiara Canonica, Giorgio Walter Senna, Gianenrico World Allergy Organ J Original Research BACKGROUND: Asthma mortality has declined since the 1980s. Nevertheless the World Health Organization (WHO) identified asthma as responsible for 225.000 deaths worldwide in 2005, and 430.000 fatal cases are expected by 2030. Some unexpected and concentrated fatal asthma events all occurred between 2013 and 2015 in Veneto, a North Eastern region of Italy, which prompted a more in-depth investigation of characteristics and risk factors. METHODS: A web search including key words related to fatal asthma in Italy between 2013 and 2015 has been performed. Concerning the cases that occurred in Veneto, subjects’ clinical records have been evaluated and details about concomitant weather conditions, pollutants and pollen count have been collected. RESULTS: Twenty-three cases of asthma deaths were found in Italy; 16 of them (69%) occurred in the Veneto Region. A prevalence of male and young age was observed. Most of patients were atopic, died in the night-time hours and during the weekends. The possible risk factors identified were the sensitization to alternaria, previous near fatal asthma attacks and the incorrect treatment of the disease. Weather condition did not appear to be related to the fatal exacerbations, whereas among the pollutants only ozone was detected over the accepted limits. Smoking habits, possible drug abuse and concomitant complementary therapies might be regarded as further risk factors. DISCUSSION: Although not free from potential biases, our web search and further investigations highlight an increasing asthma mortality trend, similarly to what other observatories report. The analysis of available clinical data suggests that the lack of treatment more than a severe asthma phenotype characterizes the fatal events. CONCLUSIONS: Asthma mortality still represents a critical issue in the management of the disease, particularly in youngsters. Once more the inadequate treatment and the lack of adherence seem to be not only related to the uncontrolled asthma but also to asthma mortality. BioMed Central 2016-12-14 /pmc/articles/PMC5155395/ /pubmed/28031774 http://dx.doi.org/10.1186/s40413-016-0129-9 Text en © Vianello et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Original Research Vianello, Andrea Caminati, Marco Crivellaro, Mariangiola El Mazloum, Rafi Snenghi, Rossella Schiappoli, Michele Dama, Annarita Rossi, Andrea Festi, Giuliana Marchi, Maria Rita Bovo, Chiara Canonica, Giorgio Walter Senna, Gianenrico Fatal asthma; is it still an epidemic? |
title | Fatal asthma; is it still an epidemic? |
title_full | Fatal asthma; is it still an epidemic? |
title_fullStr | Fatal asthma; is it still an epidemic? |
title_full_unstemmed | Fatal asthma; is it still an epidemic? |
title_short | Fatal asthma; is it still an epidemic? |
title_sort | fatal asthma; is it still an epidemic? |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155395/ https://www.ncbi.nlm.nih.gov/pubmed/28031774 http://dx.doi.org/10.1186/s40413-016-0129-9 |
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