Cargando…

The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment

Alpaca-derived single-domain antibody fragments (VHHs) that target the influenza A virus nucleoprotein (NP) can protect cells from infection when expressed in the cytosol. We found that one such VHH, αNP-VHH1, exhibits antiviral activity similar to that of Mx proteins by blocking nuclear import of i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hanke, Leo, Knockenhauer, Kevin E., Brewer, R. Camille, van Diest, Eline, Schmidt, Florian I., Schwartz, Thomas U., Ploegh, Hidde L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156300/ https://www.ncbi.nlm.nih.gov/pubmed/27965447 http://dx.doi.org/10.1128/mBio.01569-16

Ejemplares similares

Phenotypic lentivirus screens to identify functional single domain antibodies
por: Schmidt, Florian I., et al.
Publicado: (2016)

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly
por: Schmidt, Florian I., et al.
Publicado: (2016)

Identification of influenza A nucleoprotein as an antiviral target
por: Kao, Richard Y, et al.
Publicado: (2010)

A nanobody suite for yeast scaffold nucleoporins provides details of the nuclear pore complex structure
por: Nordeen, Sarah A., et al.
Publicado: (2020)

Identification of influenza A nucleoprotein body domain residues essential for viral RNA expression expose antiviral target
por: Davis, Alicia M., et al.
Publicado: (2017)

Selection and Characterization of Single-Domain Antibodies for Detection of Lassa Nucleoprotein
por: Anderson, George P., et al.
Publicado: (2020)

Neutralization of Junín virus by single domain antibodies targeted against the nucleoprotein
por: Linero, Florencia, et al.
Publicado: (2018)

An Anti-Influenza Virus Antibody Inhibits Viral Infection by Reducing Nucleus Entry of Influenza Nucleoprotein
por: Yoon, Aerin, et al.
Publicado: (2015)

Monomeric Nucleoprotein of Influenza A Virus
por: Chenavas, Sylvie, et al.
Publicado: (2013)

Influenza Nucleoprotein Delivered with Aluminium Salts Protects Mice from an Influenza A Virus That Expresses an Altered Nucleoprotein Sequence
por: MacLeod, Megan K. L., et al.
Publicado: (2013)

A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes
Publicado: (1989)

Using mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development
por: Liu, Chia-Lin, et al.
Publicado: (2016)

Interaction between influenza A virus nucleoprotein and PB2 cap-binding domain is mediated by RNA
por: Szeto, Wun-Chung, et al.
Publicado: (2020)

Potential antiviral peptides against the nucleoprotein of SARS-CoV-2
por: Mahdi, Iktedar, et al.
Publicado: (2022)

Binding of RNA by the Nucleoproteins of Influenza Viruses A and B
por: Labaronne, Alice, et al.
Publicado: (2016)

CpG 1018 Is an Effective Adjuvant for Influenza Nucleoprotein
por: Li, Yibo, et al.
Publicado: (2023)

Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity
por: Caddy, Sarah L, et al.
Publicado: (2020)

Intermediates in the Assembly and Degradation of Class I Major Histocompatibility Complex (MHC) Molecules Probed with Free Heavy Chain–specific Monoclonal Antibodies
por: Machold, Robert P., et al.
Publicado: (1996)

A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein
por: Kakisaka, Michinori, et al.
Publicado: (2015)

Detection of antibodies against avian influenza virus by protein microarray using nucleoprotein expressed in insect cells
por: ZHAO, Yuhui, et al.
Publicado: (2014)

Unveiling a Drift Resistant Cryptotope within Marburgvirus Nucleoprotein Recognized by Llama Single-Domain Antibodies
por: Garza, John Anthony, et al.
Publicado: (2017)

Targeting APOBEC3A to the viral nucleoprotein complex confers antiviral activity
por: Goila-Gaur, Ritu, et al.
Publicado: (2007)

Interactions between the Nucleoprotein and the Phosphoprotein of Pneumoviruses: Structural Insight for Rational Design of Antivirals
por: Decool, Hortense, et al.
Publicado: (2021)

Genome-wide analysis of influenza viral RNA and nucleoprotein association
por: Lee, Nara, et al.
Publicado: (2017)

Differential Behaviours and Preferential Bindings of Influenza Nucleoproteins on Importins-α
por: Donchet, Amélie, et al.
Publicado: (2020)

Structure of an H3N2 influenza virus nucleoprotein
por: Knight, Michael L., et al.
Publicado: (2021)

Novel Camelid Antibody Fragments Targeting Recombinant Nucleoprotein of Araucaria hantavirus: A Prototype for an Early Diagnosis of Hantavirus Pulmonary Syndrome
por: Pereira, Soraya S., et al.
Publicado: (2014)

Nuclease Activity of the Junín Virus Nucleoprotein C-Terminal Domain
por: Sierra, Alicia Armella, et al.
Publicado: (2023)

Generation and Characterization of Anti-Filovirus Nucleoprotein Monoclonal Antibodies
por: Rahim, Md Niaz, et al.
Publicado: (2019)

Chemoenzymatic Site-Specific Labeling of Influenza Glycoproteins as a Tool to Observe Virus Budding in Real Time
por: Popp, Maximilian Wei-Lin, et al.
Publicado: (2012)

Structure function studies on different structural domains of nucleoprotein of H1N1 subtype
por: Salahuddin, Parveen, et al.
Publicado: (2010)

Monoclonal antibody targeting a novel linear epitope on nucleoprotein confers pan-reactivity to influenza A virus
por: Gu, Min, et al.
Publicado: (2023)

Use of (18)F-2-Fluorodeoxyglucose to Label Antibody Fragments for Immuno-Positron Emission Tomography of Pancreatic Cancer
por: Rashidian, Mohammad, et al.
Publicado: (2015)

Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development
por: Chutiwitoonchai, Nopporn, et al.
Publicado: (2017)

Genetic variations on 31 and 450 residues of influenza A nucleoprotein affect viral replication and translation
por: Hung, Su-Jhen, et al.
Publicado: (2020)

The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes
por: Turrell, Lauren, et al.
Publicado: (2013)

Engineered self-assembling monolayers for label free detection of influenza nucleoprotein
por: Le Brun, Anton P., et al.
Publicado: (2015)

The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein
por: Liu, Ming, et al.
Publicado: (2015)

M2e-Based Influenza Vaccines with Nucleoprotein: A Review
por: Tan, Mei Peng, et al.
Publicado: (2021)

Migration of Influenza Virus Nucleoprotein into the Nucleolus Is Essential for Ribonucleoprotein Complex Formation
por: Miyamoto, Sho, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bllv7t4vffpjsb6trhla5aebcp