Orchestrated Action of PP2A Antagonizes Atg13 Phosphorylation and Promotes Autophagy after the Inactivation of TORC1

Target of rapamycin complex 1 (TORC1) phosphorylates autophagy-related Atg13 and represses autophagy under nutrient-rich conditions. However, when TORC1 becomes inactive upon nutrient depletion or treatment with the TORC1 inhibitor rapamycin, Atg13 dephosphorylation occurs rapidly, and autophagy is...

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Detalles Bibliográficos
Autores principales: Yeasmin, Akter MST, Waliullah, Talukdar Muhammad, Kondo, Akihiro, Kaneko, Atsuki, Koike, Naoki, Ushimaru, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156417/
https://www.ncbi.nlm.nih.gov/pubmed/27973551
http://dx.doi.org/10.1371/journal.pone.0166636

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